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CuSO4-D-glucose, an inexpensive and eco-efficient catalytic system: direct access to diverse quinolines through modified Friedlander approach involving SNAr/reduction/annulation cascade in one pot

机译:CusO4-D-葡萄糖,廉价和生态效率的催化系统:通过改进的弗里德兰德方法直接进入各种喹啉,涉及一个锅中的SNAR / REASSENT / ANNURING CASCADE

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摘要

A highly efficient and scalable multicomponent domino reaction for the synthesis of functionalized/annulated quinolines is devised directly from 2-bromoaromatic aldehydes/ketones in H2O-EtOH mixture for the first time. The key to this reaction is the use of an air-stable, eco-efficient and inexpensive CuSO4-D-glucose catalyst system, which is able to catalyze multiple transformations in one pot. The approach is carbon-economic and relies on sequential SNAr/reduction/Friedlander annulation steps, forming C-C and C-N bonds by cleavage of the Csp2-Br bond in a single synthetic operation. The reaction has a broad substrate scope and affords products in good to excellent yields.
机译:第一次直接从H 2 O-EtOH混合物中直接从2-溴芳族醛/酮直接从2-溴芳族醛/酮方向上进行高效且可缩放的多组分Domino反应。 该反应的关键是使用空气稳定,生态效率和廉价的CUSO4-D-葡萄糖催化剂体系,其能够催化一个罐中的多个转化。 该方法是碳化的,并依赖于顺序的SNAR /减少/弗里兰德网,通过在单一的合成操作中通过切割CSP2-BR键来形成C-C和C-N键。 反应具有宽的基材范围,并提供优异的产率的产品。

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  • 来源
    《RSC Advances》 |2015年第10期|共7页
  • 作者单位

    Banaras Hindu Univ Fac Sci Dept Chem Varanasi 221005 Uttar Pradesh India;

    Banaras Hindu Univ Fac Sci Dept Chem Varanasi 221005 Uttar Pradesh India;

    Banaras Hindu Univ Fac Sci Dept Chem Varanasi 221005 Uttar Pradesh India;

    Banaras Hindu Univ Fac Sci Dept Chem Varanasi 221005 Uttar Pradesh India;

    Banaras Hindu Univ Fac Sci Dept Chem Varanasi 221005 Uttar Pradesh India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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