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首页> 外文期刊>RSC Advances >A practical and novel 'standard addition' strategy to screen pharmacodynamic components in traditional Chinese medicine using Heishunpian as an example
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A practical and novel 'standard addition' strategy to screen pharmacodynamic components in traditional Chinese medicine using Heishunpian as an example

机译：利用Heishunpian作为示例，将药物动力学组分筛选中药药动力学组分的实用和新的“标准添加”策略

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摘要

The study of pharmacodynamic components in traditional Chinese medicine (TCM) is very important for future drug development and quality control of TCM. The present study established a new method for screening pharmacodynamic components (PCs) in TCM based on the strategy of standard addition (SA). The novel strategy was then applied to screen anti-inflammatory PCs in Heishunpian (HSP), the processed product of Aconitum carmichaeli Debx. We initially screened target components (TCs, possible PCs) by analyzing the correlation between UPLC-Q-TOF-MS fingerprints of chemical components and the anti-inflammatory efficacies of different HSP extracts. On the basis of spectrumeffect relationship (SER) analysis and TC determination, we added TC quantitatively into HSP extracts, evaluated the pharmacodynamic contribution ratios of TCs related to the original TCM using a mouse ear edema model, and compared them with the contribution ratio of the TC standard. The antiinflammatory PCs of HSP were then defined. Results showed that hypaconitine, deoxyaconitine and chasmanine were anti-inflammatory PCs in HSP with positive relations with HSP efficacy. Thus, SA was used to systematically evaluate the effect of chemical ingredients in TCM. The proposed method presents simple operation, strong feasibility and reliability, and provides a new approach for screening PCs in TCM in a manner that highlights the complexity and multi-component effects of TCM.
机译：中国中医（TCM）中药效学成分的研究对于未来的药物开发和中医的质量控制非常重要。本研究确定了基于标准添加策略（SA）的TCM中筛选药效学组分（PC）的新方法。然后将新的策略应用于Heishunpian（HSP）的筛选抗炎PC，Aconitum Carmichaeli Debx的加工产品。我们首先通过分析化学成分的UPLC-Q-TOF-MS指纹图与不同HSP提取物的抗炎效果之间的相关性筛选目标组分（TCS，可能的PC）。基于光谱截止关系（SER）分析和TC测定，我们将TC定量添加到HSP提取物中，评估了使用鼠标耳朵水肿模型与原始TCM相关的TCS的药效学贡献比，并将其与贡献比进行了比较TC标准。然后定义HSP的抗炎PC。结果表明，低氧化丁，脱氧遗传酮和己酰胺是HSP中的抗炎PC，与HSP疗效正相关。因此，SA用于系统地评估化学成分在中医的作用。该方法提出了简单的操作，强大的可行性和可靠性，并提供了一种新方法，用于以突出TCM的复杂性和多分量效应的方式筛选TCM中的PC。

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  • 来源
    《RSC Advances》 |2015年第28期|共8页
  • 作者

    Li Yubo; Wang Yuan; Yang Bin; Wang Yuming; Hou Zhiguo; Li Aizhu; Xu Yanyan; Ju Liang; Wu Huanyu; Zhang Yanjun;

  • 作者单位

    Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Sch Tradit Chinese Mat Med Tianjin 300193 Peoples R China;

    Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Sch Tradit Chinese Mat Med Tianjin 300193 Peoples R China;

    Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Sch Tradit Chinese Mat Med Tianjin 300193 Peoples R China;

    Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Sch Tradit Chinese Mat Med Tianjin 300193 Peoples R China;

    Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Sch Tradit Chinese Mat Med Tianjin 300193 Peoples R China;

    Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Sch Tradit Chinese Mat Med Tianjin 300193 Peoples R China;

    Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Sch Tradit Chinese Mat Med Tianjin 300193 Peoples R China;

    Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Sch Tradit Chinese Mat Med Tianjin 300193 Peoples R China;

    Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Sch Tradit Chinese Mat Med Tianjin 300193 Peoples R China;

    Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Sch Tradit Chinese Mat Med Tianjin 300193 Peoples R China;

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  • 中图分类 化学;
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