Microwave-assisted telescoped cross metathesis-ring closing aza-Michael reaction sequence: step-economical access to nicotine-lobeline hybrid analogues

Drege E.; Oko J.; Venot P. -E.; Gigant N.; Joseph D.

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Microwave-assisted telescoped cross metathesis-ring closing aza-Michael reaction sequence: step-economical access to nicotine-lobeline hybrid analogues

机译：微波辅助伸缩交叉复分离环关闭AZA-MICHAEL反应顺序：步进 - 经济进入尼古丁 - 叶列杂交类似物

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A series of 2,5-disubstituted pyrrolidines was synthesized through an efficient telescoped cross-metathesis/cyclizing aza-Michael addition involving N-heteroaromatic olefinic derivatives. This synthetic route was applied to the preparation of original nicotine-lobeline, nicotine-pelletierine and lobeline-nicotine-epibatidine hybrids.

机译：通过涉及N-杂芳烯烃衍生物的有效伸缩的交叉复分解/环化AZA-MICHAEL添加，合成了一系列2,5-二取代的吡咯。将该合成途径应用于原始尼古丁 - 鳞片，尼古丁 - 薄树和尼古丁 - 尼古丁杂交物的制备。

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《RSC Advances》 |2015年第117期|共5页
作者
Drege E.; Oko J.; Venot P. -E.; Gigant N.; Joseph D.;
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Univ Paris 11 Equipe Chim Subst Nat BioCIS Univ Paris Saclay F-92296 Chatenay Malabry France;

Univ Paris 11 Equipe Chim Subst Nat BioCIS Univ Paris Saclay F-92296 Chatenay Malabry France;

Univ Paris 11 Equipe Chim Subst Nat BioCIS Univ Paris Saclay F-92296 Chatenay Malabry France;

Univ Paris 11 Equipe Chim Subst Nat BioCIS Univ Paris Saclay F-92296 Chatenay Malabry France;

Univ Paris 11 Equipe Chim Subst Nat BioCIS Univ Paris Saclay F-92296 Chatenay Malabry France;

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正文语种 eng
中图分类化学;
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1. Microwave-assisted telescoped cross metathesis-ring closing aza-Michael reaction sequence: step-economical access to nicotine-lobeline hybrid analogues [J] . Drege E., Oko J., Venot P. -E., RSC Advances . 2015,第117期

机译：微波辅助伸缩交叉复分离环关闭AZA-MICHAEL反应顺序：步进 - 经济进入尼古丁 - 叶列杂交类似物
2. Step-economical access to valuable Weinreb amide 2,5-disubstituted pyrrolidines by a sequential one-pot two-directional cross-metathesis/cyclizing aza-Michael process [J] . Boufroura H., Mauduit M., Drège E., The Journal of Organic Chemistry . 2013,第6期

机译：通过连续一锅双向交叉复分解/环化aza-Michael方法经济高效地获得有价值的Weinreb酰胺2,5-二取代的吡咯烷
3. Microwave-Assisted Tandem Cross Metathesis Intramolecular Aza-Michael Reaction: An Easy Entry to Cyclic β-Amino Carbonyl Derivatives [J] . Santos Fustero, Diego Jimenez, Maria Sanchez-Rosello, Journal of the American Chemical Society . 2007,第21期

机译：微波辅助串联交叉复分解分子内的Aza-Michael反应：容易进入环状β-氨基羰基衍生物。
4. Tandem Cross Metathesis-Intramolecular Aza-Michael reaction. An Easy Entry to Cyclic β-Aminocarbonyl Derivatives(Abstracts) [C] . Carlos del Pozo, Jose Luis Acena, Diego Jimenez European Symposium on Organic Chemistry . 2007

机译：串联交叉复分解 - 分子内AZA-MICHAEL反应。易进入环状β-氨基羰基衍生物（摘要）
5. How close is close enough: Studies of impact parameter dependence of a reaction using laser and crossed beam techniques. [D] . Zhao, Daqing. 1991

机译：足够接近的程度：使用激光和交叉光束技术研究反应对冲击参数的依赖性。
6. Diastereoselective auxiliary- and catalyst-controlled intramolecular aza-Michael reaction for the elaboration of enantioenriched 3-substituted isoindolinones. Application to the synthesis of a new pazinaclone analogue [O] . Romain Sallio, Stéphane Lebrun, Frédéric Capet, 2018

机译：非对映选择性辅助和催化剂控制的分子内氮杂-迈克尔反应用于制备对映体富集的3-取代的异吲哚满酮。在合成新的哌嗪酮类似物中的应用
7. Microwave-Assisted Tandem Cross Metathesis Intramolecular Aza-Michael Reaction: An Easy Entry to Cyclic b-Amino Carbonyl Derivatives [O] . -1

机译：微波辅助串联交叉复分体岩分子质AZA-MICHAEL反应：对环氨基羰基衍生物的易于进入

Microwave-assisted telescoped cross metathesis-ring closing aza-Michael reaction sequence: step-economical access to nicotine-lobeline hybrid analogues

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