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A potential-gated molecularly imprinted smart electrode for nicotinamide analysis

机译：用于烟酰胺分析的潜在的分子印迹智能电极

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摘要

Triggered surface responsiveness paves the way for smart sensor technologies that not only have tunable retention, but also provide sensing through a 'built-in' programming of electrode material. In this study, we report a potential-gated electrochemical sensor for determination of nicotinamide (NAM) based on a molecularly imprinted overoxidised polypyrrole electrode. The sensitive layer was prepared by electropolymerisation of pyrrole on a glassy carbon electrode in the presence of NAM as a template molecule, followed by alkali extraction. Electrochemical methods were used to monitor the processes of electropolymerisation, template removal and binding in the presence of a [Fe(CN)(6)](3-)/[Fe(CN)(6)](4-) redox couple as an electrochemical probe. Several factors affecting the performance of the MIP-modified electrode were investigated and optimized. The peak current of the ferro/ferricyanide couple decreased linearly with successive addition of NAM in the concentration range 0.9 x 10(-6) to 9.9 x 10(-3) M with a detection limit of 1.7 x 10(-7) M (S/N = 3). The molecularly-imprinted polymer (MIP) electrode had excellent recognition capability for NAM compared to structurally related molecules. Moreover, the reproducibility and repeatability of the NAM-imprinted electrode were all found to be satisfactory. The results from sample analysis confirmed the applicability of the NAM-imprinted electrode to reusable quantitative analysis in commercial pharmaceutical samples.
机译：触发的表面响应性为智能传感器技术铺平了不仅具有可调保留的智能传感器技术的方式，而且还通过“内置”电极材料编程提供感知。在这项研究中，我们报告了一种基于分子印迹的过氧化的聚吡咯电极测定烟酰胺（NAM）的潜在门控电化学传感器。通过在NAM存在下作为模板分子的玻璃状碳电极上的吡咯对玻璃碳电极的电聚合来制备敏感层。电化学方法用于监测[Fe（CN）（6）]（3 - ）/ [Fe（6）（6）redox夫妇的情况下在[Fe（CN）（6）]（3 - ）/ [Fe（6）]（4-）氧化还原的情况下进行电解聚合物，模板去除和结合的过程。电化学探针。研究了几种影响MIP改性电极性能的因素并进行了优化。浓度范围为0.9×10（ - 6）至9.9×10（-3）m的连续添加NAM，铁/铁氰化物夫妇的峰值电流随线加入NAM，检测限为1.7×10（ - 7）m（ s / n = 3）。与结构相关的分子相比，分子印迹聚合物（MIP）电极具有优异的NAM识别能力。此外，Nam印迹电极的再现性和可重复性都被发现令人满意。样品分析的结果证实了Nam印迹电极的适用性在商业药物样品中的可重复使用定量分析。

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  • 来源
    《RSC Advances》 |2015年第44期|共8页
  • 作者

    Karimian Najmeh; Zavar Mohammad Hossein Arbab; Chamsaz Mahmoud; Ashraf Narges; Turner Anthony P. F.; Tiwari Ashutosh;

  • 作者单位

    Linkoping Univ Biosensors &

    Bioelect Ctr Dept Phys Chem &

    Biol IFM S-58183 Linkoping Sweden;

    Ferdowsi Univ Mashhad Dept Chem Fac Sci Mashhad Iran;

    Ferdowsi Univ Mashhad Dept Chem Fac Sci Mashhad Iran;

    Ferdowsi Univ Mashhad Dept Chem Fac Sci Mashhad Iran;

    Linkoping Univ Biosensors &

    Bioelect Ctr Dept Phys Chem &

    Biol IFM S-58183 Linkoping Sweden;

    Linkoping Univ Biosensors &

    Bioelect Ctr Dept Phys Chem &

    Biol IFM S-58183 Linkoping Sweden;

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  • 正文语种 eng
  • 中图分类 化学;
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