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首页> 外文期刊>RSC Advances >Redox-sensitive mesoporous silica nanoparticles functionalized with PEG through a disulfide bond linker for potential anticancer drug delivery
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Redox-sensitive mesoporous silica nanoparticles functionalized with PEG through a disulfide bond linker for potential anticancer drug delivery

机译：用二硫键键合接头用PEG官能化的氧化还原敏感的介孔二氧化硅纳米颗粒，用于潜在的抗癌药物递送

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摘要

In this paper, redox-sensitive mesoporous silica nanoparticles functionalized with polyethylene glycol (PEG) through a disulfide bond linker (MSNs-SS-PEG) were successfully synthesized using silica nanoparticles modified with a thiol group (MSNs-SH) and thiol-functionalized methoxy polyethylene glycol (MeOPEG-SH). Meanwhile, the particle size, pore size and structural properties of these materials were characterized by transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and nitrogen adsorption-desorption measurements. Furthermore, the in vitro drug release behaviour of DOX-loaded MSNs-SS-PEG (DOX@MSNs-SS-PEG) was investigated. It was shown that DOX release was markedly accelerated with the increasing concentration of glutathione (GSH), while DOX was not released from the carrier materials in the absence of GSH. Cytotoxicity evaluation revealed the good biocompatibility of the blank nanoparticles and the DOX@MSNs-SS-PEG exhibited comparative anticancer activity to free DOX towards BEL-7402 cells. Therefore, the MSNs-SS-PEG might be a great potential carrier for anticancer drug delivery.
机译：在本文中，使用二硫键键合接头（MSNS-SS-PEG）用二硫乙二醇（MSNS-SS-PEG）官能化的氧化氢敏感性介孔二氧化硅纳米粒子用硅胶纳米粒子（MSNS-SH）和硫醇官能化甲氧基成功地合成聚乙二醇（Meopeg-sh）。同时，通过透射电子显微镜（TEM），现场发射扫描电子显微镜（Fe-SEM），动态光散射（DLS），傅里叶变换红外光谱（FT-IR）表征这些材料的粒度，孔径和结构性能。（FE-IR ），X射线衍射（XRD）和氮吸附 - 解吸测量。此外，在体外药物释放装载DOX的MSN-SS-PEG的（DOX @的MSN-SS-PEG）行为进行了研究。结果表明，随着谷胱甘肽（GSH）的浓度增加，DOX释放显着加速，而在没有GSH的情况下，DOX未从载体材料中释放。细胞毒性评价揭示了坯料纳米颗粒的良好生物相容性，DOX @ MSNS-SS-PEG对Bel-7402细胞的自由DOX表现出比较的抗癌活性。因此，MSNS-SS-PEG可能是抗癌药物递送的巨大潜在载体。

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  • 来源
    《RSC Advances》 |2015年第73期|共7页
  • 作者

    Gong Huameng; Xie Zhifei; Liu Mingxing; Zhu Hongda; Sun Honghao;

  • 作者单位

    Hubei Univ Technol Hubei Prov Cooperat Innovat Ctr Ind Fermentat Sch Food &

    Pharmaceut Engn Key Lab Fermentat Engn Minist Educ Wuhan 430068 Peoples R China;

    Hubei Univ Technol Hubei Prov Cooperat Innovat Ctr Ind Fermentat Sch Food &

    Pharmaceut Engn Key Lab Fermentat Engn Minist Educ Wuhan 430068 Peoples R China;

    Hubei Univ Technol Hubei Prov Cooperat Innovat Ctr Ind Fermentat Sch Food &

    Pharmaceut Engn Key Lab Fermentat Engn Minist Educ Wuhan 430068 Peoples R China;

    Hubei Univ Technol Hubei Prov Cooperat Innovat Ctr Ind Fermentat Sch Food &

    Pharmaceut Engn Key Lab Fermentat Engn Minist Educ Wuhan 430068 Peoples R China;

    Hubei Univ Technol Hubei Prov Cooperat Innovat Ctr Ind Fermentat Sch Food &

    Pharmaceut Engn Key Lab Fermentat Engn Minist Educ Wuhan 430068 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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