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首页> 外文期刊>RSC Advances >Dietary flavone chrysin (5,7-dihydroxyflavone ChR) functionalized highly-stable metal nanoformulations for improved anticancer applications
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Dietary flavone chrysin (5,7-dihydroxyflavone ChR) functionalized highly-stable metal nanoformulations for improved anticancer applications

机译：膳食黄酮蛹（5,7-二羟基氟苯CHR）官能化高度稳定的金属纳米型，用于改进的抗癌应用

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摘要

Nanomaterials of noble metals with unique size, shape and composition receives much attention owing to their versatile functionality in personalized cancer nanomedicine. Chrysin (ChR), a natural anticancer bioflavonoid, emerged as a potential drug therapy for almost all types of cancer, however it has poor solubility and bioavailability. Herein, we report a new approach to formulate biofunctionalized metallic silver (ChR-AgNPs) and gold (ChR-AuNPs) nanoparticles using ChR as a direct bioreductant and capping agent. Size and dispersity of nanoparticles (NPs) were controlled through fixing different reaction conditions such as the temperature, pH, concentration of metal ion, stoichiometric proportion of the reaction mixture and incubation time based on their optical properties and SPR effect in UV-visible spectroscopy. The role of hydroxyl and carbonyl groups in functionalizing the metal ions with ChR was confirmed with Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) analysis. It was also substantiated that the oxygen group from ChR donates electrons to metal ion and results in complexation; ionic Ag+ and Au3+ were reduced to Ag0 and Au0 nano-forms. The physiochemical state of obtained NPs was characterized through different exclusive instrumentation, which shows the presence of highly-stable, spherical, crystalline ChR-AgNPs and ChR-AuNPs with an average size of 14 ± 6 nm and 6 ± 2 nm respectively. In vitro anticancer results revealed that the formulated metallic NPs exhibit enhanced cytotoxicity over ChR in the treatment of two different breast carcinoma cell lines (MDA-MB-231 and MDA-MB-468). Furthermore, it was evident that the NPs cause cell death via the induction of apoptosis. A hemolysis assay with human erythrocytes demonstrates good blood biocompatibility of the NPs. Thus, the ChR functionalized metal NPs can be potentially employed as a combinational drug-nano platform for breast cancer therapy.
机译：贵金属纳米材料具有独特的尺寸，形状和组成，由于它们在个性化癌症纳米医学中的多功能功能而受到巨大的关注。 Chrysin（Chr）是一种天然抗癌生物鳞状类，作为几乎所有类型的癌症的潜在药物治疗，但它具有差的溶解性和生物利用度。在此，我们报告了使用Chl作为直接生物利用剂和封端剂配制生物官能化金属银（Chr-AgNP）和金（Chr-AUNPS）纳米颗粒的新方法。通过固定不同的反应条件，根据温度，pH值，反应混合物的化学计量比例，化学计量比例和培养时间来控制纳米颗粒（NPS）的尺寸和分散性，并基于其光学性质和UV可见光谱法在紫外线效果中进行温育时间。用傅里叶变换红外光谱（FTIR）和X射线光电子体光谱（XPS）分析证实了羟基和羰基与CHR官能化金属离子的作用。还证实了来自Chr的氧基团向金属离子捐赠电子并导致络合;将离子Ag +和Au3 +降至Ag0和Au0纳米形式。获得的NPS的生理化学状态是通过不同的专用仪器的特征，其显示出高度稳定，球形，晶体Chr-agnps和平均尺寸分​​别为14±6nm和6±2nm的Chr-aUnps的存在。体外抗癌结果表明，配制的金属NPS在治疗两种不同的乳腺癌细胞系（MDA-MB-231和MB-468）中表现出增强的细胞毒性。此外，显然，NPS通过诱导细胞凋亡引起细胞死亡。用人红细胞的溶血测定证明了NPS的良好血液生物相容性。因此，CHR官能化金属NPS可以是乳腺癌治疗的组合药物 - 纳米平台。

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  • 来源
    《RSC Advances》 |2015年第109期|共10页
  • 作者

    G. Sathishkumar; Rashmi Bharti; Pradeep K. Jha;

  • 作者单位

    Department of Biotechnology and Genetic Engineering Bharathidasan University Tiruchirappalli-620024 Tamilnadu India.;

    School of Medical Science &

    Technology Indian Institute of Technology (IIT) Kharagpur-721302 West Bengal India;

    School of Medical Science &

    Technology Indian Institute of Technology (IIT) Kharagpur-721302 West Bengal India;

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  • 正文语种 eng
  • 中图分类 化学;
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