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首页> 外文期刊>RSC Advances >Injectable supramolecular hydrogels fabricated from PEGylated doxorubicin prodrug and alpha-cyclodextrin for pH-triggered drug delivery
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Injectable supramolecular hydrogels fabricated from PEGylated doxorubicin prodrug and alpha-cyclodextrin for pH-triggered drug delivery

机译：从聚乙二醇化的多柔比星产物和α-环糊精制备的可注射的超分子水凝胶，用于pH-触发的药物递送

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摘要

Supramolecular hydrogels, which are held together by noncovalent bonds and show responses to external stimuli, are of great interest in therapeutic delivery and tissue engineering as the injectable depot systems. To obtain a supramolecular hydrogel with multifunctions, such as low cytotoxicity, injectability and stimuli-triggered drug release, we herein report on the synthesis and characterization of a supramolecular hydrogel, which was formed by host-guest interaction between alpha-cyclodextrin (alpha-CD) and a PEGylated doxorubicin prodrug linked with an acid-cleavable hydrazone group (mPEG-Hyd-DOX). The polymeric prodrug displayed lower cytotoxicity than the free DOX. The host-guest interaction was demonstrated by X-ray diffraction (XRD) analysis. The structures and morphologies of the supramolecular hydrogels were systematically investigated by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The sol-gel transition process was monitored by dynamic and steady rheological analysis. The hydrogels could be degraded in the acidic environment of tumor cells and achieved the controlled delivery of DOX. The results of the pH-responsive property, in vitro cytotoxicity and drug release revealed that the supramolecular hydrogels can be used as a potential injectable matrix for the encapsulation and controlled release of anticancer drugs. This study provides an alternative for the construction of dual- or multi-drug delivery systems.
机译：超分子水凝胶，其通过非共价键和对外刺激的反应显示在一起，对治疗性递送和组织工程具有很大的兴趣作为可注射仓库系统。为了获得具有多点的超分子水凝胶，例如低细胞毒性，可注射性和刺激触发的药物释放，我们在本文中有关超分子水凝胶的合成和表征的报告，通过α-环糊精（α-CD之间的宿主访客相互作用形成）和与酸性可切割的腙基团（MPEG-HYD-DOX）连接的聚乙二醇化的多柔比蛋白前药。聚合物前药显示比自由DOX更低的细胞毒性。通过X射线衍射（XRD）分析证明了主机互动。通过差示扫描量热法（DSC），扫描电子显微镜（SEM）和热重分析（TGA）系统地研究了超分子水凝胶的结构和形态。通过动态和稳定的流变分析监测溶胶 - 凝胶过渡过程。水凝胶可以在肿瘤细胞的酸性环境中降解并实现了DOX的受控递送。 pH-响应性的结果，体外细胞毒性和药物释放的结果显示，超分子水凝胶可以用作抗癌药物的包封和控释释放的潜在可注射基质。本研究提供了构建双药或多药物递送系统的替代方案。

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  • 来源
    《RSC Advances》 |2015年第67期|共9页
  • 作者

    Li Fei; He Jinlin; Zhang Mingzu; Tam Kam Chiu; Ni Peihong;

  • 作者单位

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci Suzhou Key Lab Macromol Design &

    Precis Synth Jiangsu Key Lab Adv Funct Polymer Design &

    Applic Suzhou 215123 Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci Suzhou Key Lab Macromol Design &

    Precis Synth Jiangsu Key Lab Adv Funct Polymer Design &

    Applic Suzhou 215123 Peoples R China;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci Suzhou Key Lab Macromol Design &

    Precis Synth Jiangsu Key Lab Adv Funct Polymer Design &

    Applic Suzhou 215123 Peoples R China;

    Univ Waterloo Dept Chem Engn Waterloo ON N2L 3G1 Canada;

    Soochow Univ Coll Chem Chem Engn &

    Mat Sci Suzhou Key Lab Macromol Design &

    Precis Synth Jiangsu Key Lab Adv Funct Polymer Design &

    Applic Suzhou 215123 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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