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首页> 外文期刊>RSC Advances >Bio-compatible poly(ester-urethane)s based on PEG-PCL-PLLA copolymer with tunable crystallization and bio-degradation properties
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Bio-compatible poly(ester-urethane)s based on PEG-PCL-PLLA copolymer with tunable crystallization and bio-degradation properties

机译：基于PEG-PCL-PLLA共聚物的生物相容的聚（酯 - 氨基甲酸酯）S，具有可调谐结晶和生物降解性能

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摘要

Multi-block copolymer poly(ester-urethane)s with ethoxy or polyhedral oligomeric silsesquioxane (POSS) terminal functional groups were designed and synthesized by using polyethylene glycol-poly(epsilon-caprolactone)-poly(L-lactide) (PEG-PCL-PLLA) diols via urethane linkages. In addition, an efficient and green catalyst, bismuth ethylhexanoate, was used to prepare high molecular weight copolymers, and the influences of molecular compositions on the crystallinity, mechanical properties, biodegradability, cytocompatibility and blood-compatibility were systematically studied. By varying the terminal functional groups, as well as PEG, PCL and PLLA segment ratios, the materials exhibited highly tunable properties, especially including crystallinity, mechanical properties and degradation rate. Notably, these new functional materials may effectively be applied in the treatment of blood vessels because of the mentioned tunable properties.
机译：通过使用聚乙二醇 - 聚（ε-己内酯）-poly（L-丙交酯）（PEG-PCL-）设计和合成具有乙氧基或多面体寡聚倍半硅氧烷（POSS）末端官能团（POSP）末端官能团的多嵌段共聚物聚合物官能团 PLLA）二醇通过氨基甲酸酯键合。 此外，系统研究了高效且绿色催化剂，乙基己酸铋，制备高分子量共聚物，并系统地研究了分子量，机械性能，生物降解性，细胞偶联性和血液相容性对分子组合物的影响。 通过改变末端官能团，以及PEG，PCL和PLLA分段比，材料表现出高度可调性，特别是包括结晶度，机械性能和降解速率。 值得注意的是，由于所述可调谐性质，这些新的功能材料可以有效地应用于血管的治疗中。

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  • 来源
    《RSC Advances》 |2015年第96期|共11页
  • 作者

    Yin Guangzhong; Zhao Donglin; Wang Xiao; Ren Ye; Zhang Lianwei; Wu Xingxin; Nie Shaoping; Li Qifang;

  • 作者单位

    Beijing Univ Chem Technol State Key Lab Chem Resource Engn Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol State Key Lab Chem Resource Engn Beijing 100029 Peoples R China;

    Capital Med Univ Beijing Anzhen Hosp Emergency &

    Crit Care Ctr Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol State Key Lab Chem Resource Engn Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol State Key Lab Chem Resource Engn Beijing 100029 Peoples R China;

    Capital Med Univ Beijing Anzhen Hosp Emergency &

    Crit Care Ctr Beijing 100029 Peoples R China;

    Capital Med Univ Beijing Anzhen Hosp Emergency &

    Crit Care Ctr Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol State Key Lab Chem Resource Engn Beijing 100029 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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