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Injectable shear-thinning xanthan gum hydrogel reinforced by mussel-inspired secondary crosslinking

机译：由贻贝启发的二次交联加固的可注射剪切稀薄的黄原胶水凝胶

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摘要

Shear-thinning hydrogels fabricated by dynamic and weak interactions usually possess low mechanical strength, high swelling behavior and rapid corrosion/dissociation rate. A xanthan gum (XG) aqueous solution presented weak gel and shear-thinning properties due to XG double helical strand structure. In this study, we introduced a secondary chemical crosslinking network in the XG double helical strand network. Dopamine (Dopa) was conjugated to XG via an amidation reaction. The conjugated Dopa groups were oxidized by horseradish peroxidase (HRP) and H2O2 to form a crosslinked covalent network, or coordinated/oxidized by Fe3+ ions to form a crosslinked coordination/covalent network. At the early stage of the secondary crosslinking, the hydrogels displayed excellent thixotropic property. After the formation of the secondary network, the thixotropic property disappeared, but the mechanical strength, swelling ratio and degradation rate of the hydrogels were greatly improved. Both in vitro and in vivo investigations revealed that the XG-Dopa/HRP/H2O2 hydrogel was an injectable, biocompatible and biodegradable hydrogel material. This study demonstrated that forming a Dopa-mediated covalent crosslinking network in a shear-thinning hydrogel network is a facile and effective strategy for maintaining the injectable shear-thinning property as well as improving the stability and mechanical strength of the hydrogel.
机译：通过动态和弱相互作用制造的剪切稀疏水凝胶通常具有低机械强度，高膨胀行为和快速腐蚀/解离速率。由于XG双螺旋线结构，X原胶（XG）水溶液呈现较弱的凝胶和剪切稀疏性能。在这项研究中，我们在XG双螺旋网中引入了一种二级化学交联网络。多巴胺（DOPA）通过酰胺化反应缀合至XG。通过辣根过氧化物酶（HRP）和H 2 O 2氧化共轭的DOPA基团以形成交联的共价网络，或者通过Fe 3 +离子协调/氧化以形成交联的协调/共价网络。在二次交联的早期阶段，水凝胶显示出优异的触变性。在形成二次网络之后，触变性的性能消失，但水凝胶的机械强度，溶胀比率和降解率大大提高。体外和体内研究表明，XG-DOPA / HRP / H 2 O 2水凝胶是可注射的，生物相容性和可生物降解的水凝胶材料。该研究证明，在剪切稀疏水凝胶网络中形成DOPA介导的共价交联网络是一种容易和有效的策略，用于保持可注射剪切稀疏性能以及提高水凝胶的稳定性和机械强度。

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  • 来源
    《RSC Advances》 |2015年第125期|共10页
  • 作者

    Liu Zhijia; Yao Ping;

  • 作者单位

    Fudan Univ Dept Macromol Sci Collaborat Innovat Ctr Polymers &

    Polymer Composi State Key Lab Mol Engn Polymers Shanghai 200433 Peoples R China;

    Fudan Univ Dept Macromol Sci Collaborat Innovat Ctr Polymers &

    Polymer Composi State Key Lab Mol Engn Polymers Shanghai 200433 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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