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Resveratrol improves fungal ribosylation capacity through a unique mechanism

机译：白藜芦醇通过独特的机制改善真菌核糖基化能力

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摘要

Ribosylation is a significant modification conferring new complex and broadened cellular roles of compounds, but small organic molecules are rarely ribosylated. Here, we report the 3-O- and 4'-O-alpha-ribosylation of resveratrol, a phytoalexin that is exogenous to the fungus Daldinia eschscholzii IFB-TL01. The ribosylation is mechanistically due to the resveratrol-activated expression of the silent or less active fungal genes governing the ribosylation of non-fungal phytophenols. The resveratrol-induced ribosylation is also characterized by an increased expression of ribosyltransferases in concert with a rare ribosylating reaction using nicotinamide mononucleotide (NMN) as a ribose donor. The ribosylation-reduced toxicity of resveratrol to D. eschscholzii, along with the involvement of at least two p-glycoproteins in the glycosylation, suggests that such a glycosylation process may be a general strategy for the fungal detoxification of phenolic chemicals. The findings present an updated view of the ribosylation of small molecules, and provide direct chemogenetic evidence that will aid understanding of how phytophenols such as resveratrol function differently in the plant, microbial and animal kingdoms.
机译：核糖化是赋予化合物新的复合物和扩大细胞作用的显着改性，但是小的有机分子很少是核糖基化的。在这里，我们报告了白藜芦醇的3-O-和4'-O-α-核糖基化，这是一种对真菌Daldinia Eschscholzii IFB-TL01外部的植物脂蛋蛋白。核糖基化由于用于治疗非真菌植物核糖酚的核糖化的沉默或较少的活性真菌基因的白藜芦醇活化表达而是机械化的。白藜芦醇诱导的核糖基化的特征还通过使用烟酰胺单核苷酸（NMN）作为核糖供体的稀有核糖基化反应增加罗斯基转移酶的表达增加。白藜芦醇对D.Schscholzii的核糖化 - 降低的毒性以及至少两个糖蛋白在糖基化中的累积，表明这种糖基化方法可以是酚类化学物质的真菌解毒的一般策略。结果表现了小分子的核糖化化的更新视图，并提供了直接的化学效果，这将有助于了解植物，微生物和动物王国中白藜芦醇等白元酚等植物中毒。

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  • 来源
    《RSC Advances》 |2015年第8期|共7页
  • 作者

    Zhao Guo-Yan; Fan Jing-Yang; Hua Cheng-Pin; Yan Wei; Chen Chao-Jun; Lu Yan-Hua; Jiao Rui-Hua; Tan Ren-Xiang;

  • 作者单位

    Nanjing Univ State Key Lab Pharmaceut Biotechnol Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ State Key Lab Pharmaceut Biotechnol Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ State Key Lab Pharmaceut Biotechnol Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ State Key Lab Pharmaceut Biotechnol Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ State Key Lab Pharmaceut Biotechnol Nanjing 210093 Jiangsu Peoples R China;

    E China Univ Sci &

    Technol State Key Lab Bioreactor Engn Shanghai 200000 Peoples R China;

    Nanjing Univ State Key Lab Pharmaceut Biotechnol Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ State Key Lab Pharmaceut Biotechnol Nanjing 210093 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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