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首页> 外文期刊>Acta biomaterialia >Passive biaxial mechanical properties and in vivo axial pre-stretch of the diseased human femoropopliteal and tibial arteries
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Passive biaxial mechanical properties and in vivo axial pre-stretch of the diseased human femoropopliteal and tibial arteries

机译：患病的人股pop动脉和胫骨动脉的被动双轴力学性能和体内轴向预拉伸

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Surgical and interventional therapies for atherosclerotic lesions of the infrainguinal arteries are notorious for high rates of failure. Frequently, this leads to expensive reinterventions, return of disabling symptoms or limb loss. Interaction between the artery and repair material likely plays an important role in reconstruction failure, but data describing the mechanical properties and functional characteristics of human femoropopliteal and tibial arteries are currently not available. Diseased superficial femoral (SFA, n = 10), popliteal (PA, n = 8) and tibial arteries (TA, n = 3) from 10 patients with critical limb ischemia were tested to determine passive mechanical properties using planar biaxial extension. All specimens exhibited large nonlinear deformations and anisotropy. Under equibiaxial loading, all arteries were stiffer in the circumferential direction than in the longitudinal direction. Anisotropy and longitudinal compliance decreased distally, but circumferential compliance increased, possibly to maintain a homeostatic multiaxial stress state. Constitutive parameters for a four-fiber family invariant-based model were determined for all tissues to calculate in vivo axial pre-stretch that allows the artery to function in the most energy efficient manner while also preventing buckling during extremity flexion. Calculated axial pre-stretch was found to decrease with age, disease severity and more distal arterial location. Histological analysis of the femoropopliteal artery demonstrated a distinct sub-adventitial layer of longitudinal elastin fibers that appeared thicker in healthier arteries. The femoropopliteal artery characteristics and properties determined in this study may assist in devising better diagnostic and treatment modalities for patients with peripheral arterial disease.
机译：臭名昭著的高失败率是臭名昭著的下动脉动脉粥样硬化病变的外科手术和介入疗法。通常，这会导致昂贵的再次干预，出现残疾症状或肢体丢失。动脉与修复材料之间的相互作用可能在重建失败中起重要作用，但是目前尚无描述人股pop动脉和胫动脉的机械特性和功能特性的数据。测试了10例严重肢体缺血患者的患病股浅（SFA，n = 10），pop（PA，n = 8）和胫骨动脉（TA，n = 3），以使用平面双轴拉伸来确定被动力学性能。所有样品均表现出较大的非线性变形和各向异性。在等双轴载荷下，所有动脉在圆周方向上比在纵向上更硬。远端的各向异性和纵向顺应性降低，但周向顺应性增加，可能维持稳态多轴应力状态。确定所有组织的基于四纤维家族不变模型的本构参数，以计算体内轴向预拉伸，从而使动脉以最节能的方式发挥功能，同时还防止四肢屈曲时的屈曲。发现轴向预拉伸随着年龄，疾病严重程度和远端动脉位置的增加而降低。股pop动脉的组织学分析表明，纵向弹性蛋白纤维有明显的外膜下层，在较健康的动脉中显得较厚。在这项研究中确定的股characteristics动脉特征和特性可能有助于为周围动脉疾病患者设计更好的诊断和治疗方式。

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