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首页> 外文期刊>Acta biomaterialia >Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis--a review.
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Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis--a review.

机译：磷酸钙涂层对增强新骨形成的意义-综述。

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摘要

A systematic analysis of results available from in vitro, in vivo and clinical trials on the effects of biocompatible calcium phosphate (CaP) coatings is presented. An overview of the most frequently used methods to prepare CaP-based coatings was conducted. Dense, homogeneous, highly adherent and biocompatible CaP or hybrid organic/inorganic CaP coatings with tailored properties can be deposited. It has been demonstrated that CaP coatings have a significant effect on the bone regeneration process. In vitro experiments using different cells (e.g. SaOS-2, human mesenchymal stem cells and osteoblast-like cells) have revealed that CaP coatings enhance cellular adhesion, proliferation and differentiation to promote bone regeneration. However, in vivo, the exact mechanism of osteogenesis in response to CaP coatings is unclear; indeed, there are conflicting reports of the effectiveness of CaP coatings, with results ranging from highly effective to no significant or even negative effects. This review therefore highlights progress in CaP coatings for orthopaedic implants and discusses the future research and use of these devices. Currently, an exciting area of research is in bioactive hybrid composite CaP-based coatings containing both inorganic (CaP coating) and organic (collagen, bone morphogenetic proteins, arginylglycylaspartic acid etc.) components with the aim of promoting tissue ingrowth and vascularization. Further investigations are necessary to reveal the relative influences of implant design, surgical procedure, and coating characteristics (thickness, structure, topography, porosity, wettability etc.) on the long-term clinical effects of hybrid CaP coatings. In addition to commercially available plasma spraying, other effective routes for the fabrication of hybrid CaP coatings for clinical use still need to be determined and current progress is discussed.
机译：本文提供了对生物相容性磷酸钙（CaP）涂层效果的体外，体内和临床试验结果的系统分析。对制备CaP基涂层的最常用方法进行了概述。可以沉积致密，均质，高附着力和生物相容性的CaP或具有定制性能的有机/无机混合CaP涂层。已经证明，CaP涂层对骨再生过程具有显着影响。使用不同细胞（例如SaOS-2，人间充质干细胞和成骨细胞样细胞）的体外实验表明，CaP涂层可增强细胞粘附，增殖和分化，从而促进骨骼再生。然而，在体内，尚不清楚响应CaP涂层的成骨作用的确切机制。确实，关于CaP涂层有效性的报道相互矛盾，结果范围从高效到无显着甚至负面影响。因此，本综述重点介绍了骨科植入物的CaP涂层的进展，并讨论了这些设备的未来研究和使用。目前，激动人心的研究领域是生物活性的复合复合CaP基涂料，既包含无机成分（CaP涂层），又包含有机成分（胶原蛋白，骨形态发生蛋白，精氨酰糖基葡萄糖酸等），目的是促进组织向内生长和血管化。有必要进行进一步的研究以揭示植入物设计，手术程序和涂层特性（厚度，结构，形貌，孔隙率，润湿性等）对混合CaP涂层的长期临床效果的相对影响。除了可商购的等离子喷涂外，仍需要确定其他制造临床用复合CaP涂层的有效途径，并讨论当前的进展。

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