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首页> 外文期刊>Acta biomaterialia >Poly(amido-amine)-based hydrogels with tailored mechanical properties and degradation rates for tissue engineering
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Poly(amido-amine)-based hydrogels with tailored mechanical properties and degradation rates for tissue engineering

机译：聚（酰胺胺）基水凝胶，具有定制的机械性能和降解速率，可用于组织工程

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摘要

Poly(amido-amine) (PAA) hydrogels containing the 2,2-bisacrylamidoacetic acid-4-amminobutyl guanidine monomeric unit have a known ability to enhance cellular adhesion by interacting with the arginin-glycin-aspartic acid (RGD)-binding αVβ3 integrin, expressed by a wide number of cell types. Scientific interest in this class of materials has traditionally been hampered by their poor mechanical properties and restricted range of degradation rate. Here we present the design of novel biocompatible, RGD-mimic PAA-based hydrogels with wide and tunable degradation rates as well as improved mechanical and biological properties for biomedical applications. This is achieved by radical polymerization of acrylamide-terminated PAA oligomers in both the presence and absence of 2-hydroxyethylmethacrylate. The degradation rate is found to be precisely tunable by adjusting the PAA oligomer molecular weight and acrylic co-monomer concentration in the starting reaction mixture. Cell adhesion and proliferation tests on Madin-Darby canine kidney epithelial cells show that PAA-based hydrogels have the capacity to promote cell adhesion up to 200% compared to the control. Mechanical tests show higher compressive strength of acrylic chain containing hydrogels compared to traditional PAA hydrogels.
机译：包含2,2-双丙烯酰胺基乙酸-4-氨基丁基胍单体单元的聚（酰胺胺）（PAA）水凝胶具有通过与精氨酸-甘氨酸-天冬氨酸（RGD）结合的αVβ3整联蛋白相互作用来增强细胞粘附的已知能力。 ，以多种细胞类型表示。传统上，这类材料的机械性能差和降解速率范围受限，一直阻碍了对此材料的科学兴趣。在这里，我们介绍了新型的生物相容性，RGD模拟的PAA基水凝胶，其降解速率宽且可调，并且针对生物医学应用具有改进的机械和生物学特性。这是通过在存在和不存在甲基丙烯酸2-羟乙酯的情况下，将丙烯酰胺封端的PAA低聚物进行自由基聚合来实现的。发现通过调节起始反应混合物中的PAA低聚物分子量和丙烯酸类共聚单体浓度可以精确地调节降解速率。对Madin-Darby犬肾上皮细胞的细胞粘附和增殖测试表明，与对照相比，基于PAA的水凝胶具有将细胞粘附的能力提高至200％的能力。机械测试表明，与传统的PAA水凝胶相比，含丙烯酸链的水凝胶具有更高的抗压强度。

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