• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Chemical sintering generates uniform porous hyaluronic acid hydrogels
【24h】

Chemical sintering generates uniform porous hyaluronic acid hydrogels

机译：化学烧结产生均匀的多孔透明质酸水凝胶

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The implantation of scaffolds for tissue repair has achieved only limited success due primarily to the inability to achieve vascularization within the construct. Many strategies have therefore moved to incorporate pores into the scaffolds to encourage rapid cellular infiltration and subsequent vascular ingrowth. We utilized an efficient chemical sintering technique to create a uniform network of polymethyl methacrylate (PMMA) microspheres for porous hyaluronic acid hydrogel formation. The porous hydrogels generated from chemical sintering possessed pore uniformity and interconnectivity comparable to the commonly used non- and heat sintering techniques. Moreover, a similar cell response to the porous hydrogels generated from each sintering approach was observed in cell viability, spreading and proliferation in vitro, as well as cellular invasion in vivo. We propose chemical sintering of PMMA microspheres using a dilute acetone solution as an alternative method to generate porous hyaluronic acid hydrogels since it requires equal or 10-fold less processing time as the currently used non-sintering or heat sintering technique, respectively.
机译：用于组织修复的支架植入仅获得有限的成功，这主要是由于无法在构建体中实现血管化。因此，已经采取了许多策略以将孔并入支架中以促进快速的细胞浸润和随后的血管向内生长。我们利用一种有效的化学烧结技术创建了聚甲基丙烯酸甲酯（PMMA）微球的均匀网络，用于多孔透明质酸水凝胶的形成。化学烧结产生的多孔水凝胶具有与常用的非烧结和热烧结技术相当的孔隙均匀性和互连性。此外，观察到了对每种烧结方法产生的多孔水凝胶的相似细胞反应，包括细胞活力，体外扩散和增殖以及体内细胞侵袭。我们建议使用稀丙酮溶液对PMMA微球进行化学烧结，作为产生多孔透明质酸水凝胶的替代方法，因为它所需的处理时间分别相当于当前使用的非烧结或热烧结技术的10倍或10倍。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号