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首页> 外文期刊>Acta biomaterialia >Nanoparticle release from dental composites
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Nanoparticle release from dental composites

机译：牙科复合材料中的纳米颗粒释放

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摘要

Dental composites typically contain high amounts (up to 60 vol.%) of nanosized filler particles. There is a current concern that dental personnel (and patients) may inhale nanosized dust particles (100 nm) during abrasive procedures to shape, finish or remove restorations but, so far, whether airborne nanoparticles are released has never been investigated. In this study, composite dust was analyzed in real work conditions. Exposure measurements of dust in a dental clinic revealed high peak concentrations of nanoparticles in the breathing zone of both dentist and patient, especially during aesthetic treatments or treatments of worn teeth with composite build-ups. Further laboratory assessment confirmed that all tested composites released very high concentrations of airborne particles in the nanorange (106 cm-3). The median diameter of airborne composite dust varied between 38 and 70 nm. Electron microscopic and energy dispersive X-ray analysis confirmed that the airborne particles originated from the composite, and revealed that the dust particles consisted of filler particles or resin or both. Though composite dust exhibited no significant oxidative reactivity, more toxicological research is needed. To conclude, on manipulation with the bur, dental composites release high concentrations of nanoparticles that may enter deeply into the lungs.
机译：牙科复合材料通常包含大量（最高60％（体积））的纳米级填料颗粒。当前，牙科人员（和患者）可能会在研磨过程中吸入纳米级灰尘颗粒（<100 nm）以定型，修整或去除修复体，但迄今为止，尚未研究是否释放出空气中的纳米颗粒。在这项研究中，在实际工作条件下分析了复合粉尘。在牙科诊所中，灰尘的暴露测量表明，在牙医和患者的呼吸区域中，纳米颗粒的峰值浓度很高，尤其是在美学治疗或复合材料磨损牙齿的治疗过程中。进一步的实验室评估证实，所有测试的复合材料均释放出纳米范围（> 106 cm-3）内非常高浓度的空气传播颗粒。空气传播的复合粉尘的中值直径在38至70 nm之间变化。电子显微镜和能量色散X射线分析证实，空气中的颗粒源自复合材料，并显示粉尘颗粒由填料颗粒或树脂或两者组成。尽管复合粉尘没有表现出明显的氧化反应性，但仍需要更多的毒理学研究。总而言之，在使用钻针进行操作时，牙科复合材料会释放出高浓度的纳米颗粒，这些纳米颗粒可能会深入肺部。

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