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首页> 外文期刊>Acta biomaterialia >Bioerodible system for sequential release of multiple drugs
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Bioerodible system for sequential release of multiple drugs

机译：可生物腐蚀的系统，可顺序释放多种药物

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摘要

Because many complex physiological processes are controlled by multiple biomolecules, comprehensive treatment of certain disease conditions may be more effectively achieved by administration of more than one type of drug. Thus, the objective of the present research was to develop a multilayered, polymer-based system for sequential delivery of multiple drugs. The polymers used were cellulose acetate phthalate (CAP) complexed with Pluronic F-127 (P). After evaluating morphology of the resulting CAPP system, in vitro release of small molecule drugs and a model protein was studied from both single and multilayered devices. Drug release from single-layered CAPP films followed zero-order kinetics related to surface erosion of the association polymer. Release studies from multilayered CAPP devices showed the possibility of achieving intermittent release of one type of drug as well as sequential release of more than one type of drug. Mathematical modeling accurately predicted the release profiles for both single layer and multilayered devices. The present CAPP association polymer-based multilayer devices can be used for localized, sequential delivery of multiple drugs for the possible treatment of complex disease conditions, and perhaps for tissue engineering applications, that require delivery of more than one type of biomolecule.
机译：由于许多生物分子控制着许多复杂的生理过程，因此通过施用一种以上的药物可以更有效地实现某些疾病的全面治疗。因此，本研究的目的是开发一种多层的，基于聚合物的系统，用于依次输送多种药物。使用的聚合物是与Pluronic F-127（P）络合的邻苯二甲酸乙酸纤维素（CAP）。在评估了所得CAPP系统的形态后，研究了从单层和多层装置中体外释放小分子药物和模型蛋白的过程。从单层CAPP膜释放的药物遵循与缔合聚合物表面腐蚀有关的零级动力学。多层CAPP装置的释放研究表明，有可能实现一种药物的间歇释放以及一种以上药物的连续释放。数学模型可以准确预测单层和多层设备的释放曲线。本发明的基于CAPP缔合聚合物的多层装置可用于多种药物的局部，顺序递送，以用于可能的复杂疾病状况的治疗，并且可能用于组织工程应用，其需要递送一种以上类型的生物分子。

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