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首页> 外文期刊>Acta Dermato-Venereologica >Analysis of the expression of cutaneous lymphocyte-associated antigen on the peripheral blood and cutaneous lymphocytes of alopecia areata patients.
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Analysis of the expression of cutaneous lymphocyte-associated antigen on the peripheral blood and cutaneous lymphocytes of alopecia areata patients.

机译：斑秃患者外周血和皮肤淋巴细胞皮肤淋巴细胞相关抗原的表达分析。

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摘要

Alopecia areata has been reported to be accompanied by abnormal autoimmune dysfunction. We examined the expression of cutaneous lymphocyte-associated antigen (CLA), which is a skin-specific lymphocyte homing receptor, in the peripheral blood lymphocytes and skin of patients with alopecia areata. In the patients' peripheral blood, the percentage of CLA-positive CD4+ or CD8+ lymphocytes, was significantly higher than that of normal controls. The patients with severe or progressive alopecia areata showed a much higher CLA-positivity compared to patients recovering from the disease. A chronological study showed that the percentage of CLA-positive peripheral blood lymphocytes, CD4 + or CD8 + lymphocytes decreased in parallel with the patients' good clinical course. The CLA-positivity in peripheral blood lymphocytes, CD4+ or CD8+ lymphocytes of patients with alopecia areata who did not respond to oral corticosteroid therapy remained higher than in those who responded well to the treatment. In the affected scalp skin, many infiltrating lymphocytes around the hair follicles, which were CD4+ or CD8+ lymphocytes, expressed CLA. These findings suggest that the CLA-positivity correlates with clinical activity and that CLA-positive CD4+ or CD8+ lymphocytes may play an important role in alopecia areata.
机译：据报道，斑秃有伴有异常的自身免疫功能障碍。我们检查了斑秃患者外周血淋巴细胞和皮肤中皮肤淋巴细胞相关抗原（CLA）的表达，这是一种皮肤特异性淋巴细胞归巢受体。在患者的外周血中，CLA阳性CD4 +或CD8 +淋巴细胞的百分比显着高于正常对照组。与从疾病中康复的患者相比，患有严重或进行性斑秃的患者表现出更高的CLA阳性。一项时序研究显示，随着患者的良好临床过程，CLA阳性外周血淋巴细胞，CD4 +或CD8 +淋巴细胞的百分比下降。对口服皮质类固醇激素治疗无效的斑秃患者外周血淋巴细胞，CD4 +或CD8 +淋巴细胞的CLA阳性率仍高于对治疗反应良好的患者。在受影响的头皮中，毛囊周围的许多浸润淋巴细胞（CD4 +或CD8 +淋巴细胞）表达CLA。这些发现表明，CLA阳性与临床活动有关，并且CLA阳性CD4 +或CD8 +淋巴细胞在斑秃中可能起重要作用。

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