Interleukin-18 levels in the plasma of psoriatic patients correlate with the extent of skin lesions and the PASI score.

Pietrzak A; Lecewicz Torun B; Chodorowska G; Rolinski J

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Interleukin-18 levels in the plasma of psoriatic patients correlate with the extent of skin lesions and the PASI score.

机译：银屑病患者血浆中的白细胞介素18水平与皮肤病变程度和PASI评分相关。

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Interleukin-18 is a cytokine with a possible role in the pathogenesis of psoriasis. We examined subpopulations of peripheral blood lymphocytes and their expression of activation markers and correlated this with plasma levels of IL-18 and clinical disease severity in patients with psoriasis. We included 12 patients with psoriasis who had a PASI score from 15 to 48 and compared them to controls. IL-18 plasma concentrations were determined with an enzyme-linked immunosorbent assay. We observed a significant correlation between the IL-18 levels and the area of skin affected with psoriasis and the PASI score. We also observed an increase in NK cells and memory helper CD45RO + /CD4+cells.

机译：白介素-18是一种细胞因子，在牛皮癣的发病机理中可能发挥作用。我们检查了银屑病患者外周血淋巴细胞亚群及其激活标志物的表达，并将其与血浆IL-18水平和临床疾病严重程度相关联。我们纳入了12例PASI评分为15至48的牛皮癣患者，并将其与对照组进行了比较。用酶联免疫吸附测定法测定IL-18血浆浓度。我们观察到IL-18水平与受牛皮癣影响的皮肤面积和PASI评分之间存在显着相关性。我们还观察到NK细胞和记忆辅助CD45RO + / CD4 +细胞的增加。

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来源
《Acta Dermato-Venereologica》 |2003年第4期|共4页
作者
Pietrzak A; Lecewicz Torun B; Chodorowska G; Rolinski J;
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正文语种 eng
中图分类皮肤病学与性病学;
关键词
Interleukin-18; Psoriasis; Plasma; Skin lesion; NOS; 白细胞介素18; 银屑病; 血浆;

机译：Interleukin-18;Psoriasis;Plasma;Skin lesion;NOS;白细胞介素18;银屑病;血浆;

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1. Interleukin-18 levels in the plasma of psoriatic patients correlate with the extent of skin lesions and the PASI score. [J] . Pietrzak A, Lecewicz Torun B, Chodorowska G, Acta Dermato-Venereologica . 2003,第4期

机译：银屑病患者血浆中的白细胞介素18水平与皮肤病变程度和PASI评分相关。
2. Circulating levels of lipocalin-2 and retinol-binding protein-4 are increased in psoriatic patients and correlated with baseline PASI [J] . Jorge Romaní, Assumpta Caixàs, Victoria Ceperuelo-Mallafré, Archives of Dermatological Research . 2013,第2期

机译：银屑病患者的脂蛋白2和视黄醇结合蛋白4的循环水平增加，并且与基线PASI相关
3. Endothelin-1 levels are increased in sera and lesional skin extracts of psoriatic patients and correlate with disease severity. [J] . Bonifati C, Mussi A, Carducci M, Acta Dermato-Venereologica . 1998,第1期

机译：银屑病患者的血清和病灶皮肤提取物中的内皮素-1水平升高，并且与疾病严重程度相关。
4. Behavioural Correlates of Dopaminergic Agonists' Dyskinetic Potential in the 6-OHDA-Lesioned Rat [C] . Anna R. Carta, Lucia Frau, Annalisa Pinna, Triennial Meeting of the International Basal Ganglia Society . 2009

机译：多巴胺能激动剂在6-OHDA损伤大鼠中的多巴胺能激动剂的行为相关性
5. Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. [D] . Kang, Guson. 2012

机译：血浆BIN1与心力衰竭相关，并预测患有心律失常的右室心肌病患者的心律失常。
6. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment [O] . Cristina Albanesi, Claudia Scarponi, Sabatino Pallotta, 2009

机译：Chemerin表达标志着早期牛皮癣皮肤病变并与浆细胞样树突状细胞募集相关
7. Accumulation of Oxidized Low-Density Lipoprotein in Psoriatic Skin and Changes of Plasma Lipid Levels in Psoriatic Patients [O] . Tekin, Nilgun Solak, Tekin, Ishak Ozel, Barut, Figen, 2007

机译：银屑病患者氧化型低密度脂蛋白的积累银屑病患者的皮肤和血浆脂质水平的变化

Interleukin-18 levels in the plasma of psoriatic patients correlate with the extent of skin lesions and the PASI score.

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