Structure of Z-(Aib)(9)OBut

Gessmann R.; Kokkinidis M.; Bruckner H.

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Structure of Z-(Aib)(9)OBut

机译：Z-（Aib）（9）OBut的结构

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The structure of the synthetic protected oligopeptide Z-(Aib)(9)OBu', tert-butoxynona(alpha-aminoisobutyric acid), which contains the unusual cr-aminoisobutyric acid (Aib), was determined by X-ray crystallography. The two independent molecules in the asymmetric unit fold into 3(10)-helices, each stabilized by seven intramolecular hydrogen bonds. The C terminus of one of the molecules is disordered and adopts a semi-extended conformation, which is rather unusual for Aib residues. This is the first observation of such a conformation involved in a disorder in Aib-containing oligopeptides. The existence of a second conformation for the C-terminal residue might explain the difficulties in crystallizing the title compound and a different behaviour of the title compound in thin layer chromatography compared with the other homopeptides. [References: 26]

机译：通过X射线晶体学测定了合成的受保护的寡肽Z-（Aib）（9）OBu'，叔丁氧基壬酸酯（α-氨基异丁酸）的结构，其包含不寻常的cr-氨基异丁酸（Aib）。不对称单元中的两个独立分子折叠成3（10）螺旋，每个螺旋均由七个分子内氢键稳定。其中一个分子的C末端是无序的，并采用半延伸构象，这对于Aib残基来说是很不寻常的。这是这种构象涉及含Aib的寡肽疾病的首次观察。 C端残基的第二种构象的存在可能解释了标题化合物结晶的困难以及与其他同系肽相比，薄层色谱法中标题化合物的行为不同。 [参考：26]

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《Acta Crystallographica, Section B. Structural Science》 |1998年第3期|共8页
作者
Gessmann R.; Kokkinidis M.; Bruckner H.;
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正文语种 eng
中图分类晶体学;
关键词
Alpha-aminoisobutyric-acid; Linear oligopeptides; Crystal-structure; Conformational-analysis; Preferred conformation; Atomic resolution; Homo-oligomers; Helix; Peptide; Preferences;

机译：α-氨基异丁酸;线性寡肽;晶体结构;构象分析;优选构象;原子拆分;均聚物;螺旋;肽;首选项;

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1. Structure of Z-(Aib)(9)OBut [J] . Gessmann R., Kokkinidis M., Bruckner H. Acta Crystallographica, Section B. Structural Science . 1998,第3期

机译：Z-（Aib）（9）OBut的结构
2. The crystal structure of Z-(Aib)(10)-OH at 0.65 angstrom resolution: three complete turns of 3(10)-helix [J] . Gessmann Renate, Brueckner Hans, Petratos Kyriacos Journal of peptide science: An official publication of the European Peptide Society . 2016,第2期

机译：Z-（Aib）（10）-OH的晶体结构，分辨率为0.65埃：3（10）-螺旋的三个完整圈
3. Reactions of silicon-, germanium- and tin-containing carbene complexes of tungsten Ph3E-C W(OBut)(3)(E = Si, Ge, Sn) with hydrogen chloride: crystal structures of carbene complexes Ph3E-CH=WCl2(OBut)(2) (E = Si, Ge) [J] . Safronova AV., Bochkarev LN., Stolyarova NE., Journal of Organometallic Chemistry . 2004,第7期

机译：钨Ph3E-C W（OBut）（3）（E = Si，Ge，Sn）的含硅，锗和锡的卡宾配合物与氯化氢的反应：卡宾配合物的晶体结构Ph3E-CH = WCl2（OBut ）（2）（E =硅，锗）
4. Enhanced Structural Damage Tolerance of CFRP Primary Structures by Z- Pin Reinforcement [C] . A. Clarke, E. Greenhalgh, C. Meeks 44th AIAA/ASME/ASCE/AHS Structures, Structural Dynamics, and Materials Conference ; 11th AIAA/ASME/AHS Adaptive Structures Conference ; 5th AIAA Non-Deterministic Approaches Forum ; 4th AIAA Gossamer Spacecraft Forum ; AIAA Dynamics Specialists Conference . 2003

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5. Integration Workplace Practices for Generation Z- an e-Delphi Study [D] . Jain, Unnatti. 2020

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6. Crystal structures of Z–Gly–Aib–O−·0.5Ca2+·H2O and Z–Gly–Aib–OH [O] . Renate Gessmann, Hans Brückner, Kyriacos Petratos 2018

机译：Z–Gly–Aib–O–·0.5Ca2 +·H2O和Z–Gly–Aib–OH的晶体结构
7. Amino acid-lanthanide interactions. Crystal structures of lanthanide complexes of Alpha-amino isobutyric acid (Aib), La2(Aib)4(H2O)8(ClO4)6 and Pr2(Aib)4(H2O)8Cl6·H2O [O] . Aparna K, Krishnamurthy SS, Nethaji M, 1994

机译：氨基酸-镧系元素相互作用。 α-氨基异丁酸（Aib），La2（Aib）4（H2O）8（ClO4）6和Pr2（Aib）4（H2O）8 Cl6·H2O的镧系元素络合物的晶体结构

Structure of Z-(Aib)(9)OBut

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