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首页> 外文期刊>Acta Cytologica: The Journal of Clinical Cytology and Cytopathology >Pero Vaz de Caminha: an-interchange Program for quality control between Brazil and Portugal.
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Pero Vaz de Caminha: an-interchange Program for quality control between Brazil and Portugal.

机译：Pero Vaz de Caminha：巴西和葡萄牙之间的质量控制互换计划。

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OBJECTIVE: To start an interexchange program for quality control in cervical cytology and discuss conceptual criteria for diagnosis. STUDY DESIGN: Slides were selected in the archives of the 2 institutes and included cases with unsatisfactory, negative and positive results. Sets of slides were changed between the partners every 3 months. At the end of each year a senior cytopathologist was invited to discuss the major discrepancies found in the study. RESULTS: A total of 1,041 cases were analyzed. Full concordance was obtained in 74.4% (774) of cases and discrepancies in 25.6% (267 cases). Full agreement was achieved in 276 (39%) of 707 cases categorized as negative. In 421 negative cases from laboratory A, this concordance represents 65.5% and 96.5% for laboratory B, which submitted 286 negative cases. The main discordance was the high number of atypical squamous cells of undetermined significance cases: 3.1% for A and 128 (33.2%) for B. Samples with discrepancies related to the quality of the material was another controversial issue: of 16 cases from laboratory A, 6 (37.5%) unsatisfactory cases were the same and 10 (62.5%) different. Laboratory B presented 20 unsatisfactory cases, and 14 (70.0%) had other diagnoses. Low grade squamous intraepithelial lesion and high grade squamous intraepithelial lesion concordance ranged from 75% to 80%, and invasive carcinoma has 4 discordances (28.5%), 3 previously screened as high grade squamous intraepithelial lesion and 1 as atypical squamous cells of undetermined significance. The kappa value obtained was 0.65, indicating substantial agreement. CONCLUSION: Our results indicated that atypical squamous cells of undetermined significance diagnoses are the crucial point of controversies and concern the quality of routine diagnosis in cytopathology.
机译：目的：启动一个用于宫颈细胞学质量控制的互通计划，并讨论诊断的概念标准。研究设计：从两个研究所的档案中选择幻灯片，其中包括结果不理想，阴性和阳性的病例。合作伙伴之间每3个月更换一组幻灯片。每年年底，一位资深细胞病理学家被邀请讨论该研究中发现的主要差异。结果：共分析1,041例。在74.4％（774）的案例中获得了完全的一致性，在25.6％（267例）的差异中获得了一致性。 707例归为阴性的病例中有276例（占39％）完全达成共识。在来自实验室A的421例阴性病例中，这一一致性代表实验室B的65.5％和96.5％，后者提交了286例阴性病例。主要不一致之处是，未确定重要病例的非典型鳞状细胞数量很多：A为3.1％，B为128（33.2％）。与材料质量有关的样品是另一个有争议的问题：来自实验室A的16例，其中6例（37.5％）不能令人满意的情况相同，而10例（62.5％）不同。实验室B提出20例不满意的病例，其中14例（70.0％）有其他诊断。低度鳞状上皮内病变和高度鳞状上皮内病变的一致度在75％至80％之间，浸润性癌有4个不一致性（28.5％），其中3个先前被筛查为高级别鳞状上皮内病变和1个未定型的非典型鳞状细胞。获得的κ值为0.65，表明基本一致。结论：我们的结果表明，未明确意义的非典型鳞状细胞癌是争论的关键点，并且关系到细胞病理学常规诊断的质量。

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