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首页> 外文期刊>Acta Cytologica: The Journal of Clinical Cytology and Cytopathology >Fine needle aspiration of poorly differentiated oxyphilic (Hurthle cell) thyroid carcinoma: a case report.
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Fine needle aspiration of poorly differentiated oxyphilic (Hurthle cell) thyroid carcinoma: a case report.

机译：低分化嗜氧性（Hurthle细胞）甲状腺癌的细针穿刺术：病例报告。

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BACKGROUND: Poorly differentiated oxyphilic (Hurthle cell) carcinomas are a more recently described variant of poorly differentiated thyroid carcinoma and are characterized by a prominent Hurthle cell component in a solid or trabecular arrangement. Clinically, poorly differentiated oxyphilic carcinomas behave more aggressively as compared to classic Hurthle cell carcinomas, which have a predominantly follicular pattern. Although the histology of these rare thyroid tumors has been reported in the literature, the cytologic features on fine needle aspiration biopsy have not been described before. CASE: A 73-year-old man with a long history of radioactive iodine and levothyroxine therapy for multinodular goiter presented with a painful, rapidly expanding, 6-cm, left thyroid mass with aggressive radiologic features. Fine needle aspiration biopsy of the mass yielded extremely cellular smears with a dual population of medium-sized follicular cells and numerous Hurthle cells. Subsequent thyroidectomy confirmedthe malignant nature of this Hurthle cell-rich tumor, warranting a diagnosis of poorly differentiated oxyphilic (Hurthle cell) thyroid carcinoma. CONCULSION: Poorly differentiated oxyphilic thyroid carcinoma is an aggressive variant of Hurthle cell carcinomas and must enter the differential diagnosis when fine needle aspiration biopsy of a radiologically aggressive thyroid mass yields extremely hypercellular smears with a prominent Hurthle cell component.
机译：背景：低分化的嗜氧性（Hurthle细胞）癌是近来描述的低分化甲状腺癌的变异体，其特征在于以固体或小梁排列的突出的Hurthle细胞成分。与经典的Hurthle细胞癌相比，在临床上，低分化的嗜氧性癌的行为更具侵略性，后者的卵泡形态主要为滤泡状。尽管在文献中已经报道了这些罕见的甲状腺肿瘤的组织学，但以前没有描述过细针穿刺活检的细胞学特征。案例：一名73岁的男性，有放射性碘和左甲状腺素治疗多结节性甲状腺肿的悠久历史，表现为疼痛迅速，扩张迅速的6厘米左甲状腺肿块，具有放射学特征。对该肿块进行细针穿刺活检可产生极度细胞涂片，其中有中等大小的滤泡细胞和众多的Hurthle细胞。随后的甲状腺切除术证实了这种富含Hurthle细胞的肿瘤的恶性性质，值得诊断为低分化的嗜氧性（Hurthle细胞）甲状腺癌。结论：分化不良的嗜氧性甲状腺癌是hurthle细胞癌的一种侵袭性变体，当放射性侵袭性甲状腺肿块的细针穿刺活检产生具有明显的urthle细胞成分的极高细胞涂片时，必须进入鉴别诊断。

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