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首页> 外文期刊>Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics >MALDI imaging mass spectrometry — From bench to bedside
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MALDI imaging mass spectrometry — From bench to bedside

机译：MALDI成像质谱 - 从长凳到床边

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摘要

Today, pathologists face many challenges in defining the precise morphomolecular diagnosis and in guiding clinicians to the optimal patients' treatment. To achieve this goal, increasingly, classical histomorphological methods have to be supplemented by high throughput molecular assays. Since MALDI imaging mass spectrometry (IMS) enables the assessment of spatial molecular arrangements in tissue sections, it goes far beyond microscopy in providing hundreds of different molecular images from a single scan without the need of target-specific reagents. Thus, this technology has the potential to uncover new markers for diagnostic purposes or markers that correlate with disease severity as well as prognosis and therapeutic response. Additionally, in the future MALDI IMS based classifiers measured with this technology in real time in the diagnostic setting might be applicable in the routine diagnostic setting. In this review, recently published studies that show the usefulness, advantages, and applicability of MALDI IMS in different fields of pathology (diagnosis, prognosis and treatment response) are highlighted. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann.
机译：今天，病理学家在定义精确的形态分子诊断和指导临床医生到最佳患者的治疗方面面临着许多挑战。为了实现这一目标，越来越多地，必须通过高通量分子测定补充典型的组织形态学方法。由于MALDI成像质谱（IMS）能够评估组织切片中的空间分子布置，因此远远超出显微镜，在没有靶特异性试剂的情况下从单次扫描提供数百种不同的分子图像时。因此，该技术具有揭示与疾病严重程度相关的诊断目的或标记的新标志物以及预后和治疗反应。此外，在未来的基于MALDI IMS在诊断设置中实时使用该技术测量的分类器可能适用于例行诊断设置。在本次审查中，最近公布的研究表明，MALDI IMS在不同病理学（诊断，预后和治疗响应）中的有用性，优势和适用性的研究被突出显示。本文是题为：Maldi成像的特殊问题的一部分，由Corinna Henkel博士和Peter Hoffmann教授编辑。

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