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首页> 外文期刊>Acta crystallographica, Section F. Structural biology and crystallization communications >Unexpected features in the Protein Data Bank entries 3qd1 and 4i8e: the structural description of the binding of the serine-rich repeat adhesin GspB to host cell carbohydrate receptor is not a solved issue
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Unexpected features in the Protein Data Bank entries 3qd1 and 4i8e: the structural description of the binding of the serine-rich repeat adhesin GspB to host cell carbohydrate receptor is not a solved issue

机译：Protein Data Bank条目3qd1和4i8e中的意外功能：富含丝氨酸的重复粘附素GspB与宿主细胞碳水化合物受体结合的结构描述尚未解决

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摘要

The structure of a complex between a fragment of the adhesin GspB from Streptococcus gordonii and a disaccharide (PDB entries 3qd1 and 4i8e) has recently been proposed to identify the binding site for the sialyl-T antigen recognized by GspB. This structure exhibits numerous unrealistic and unusual features such as an excessive number of van der Waals clashes and a lack of correlation between atomic structure and experimental electron density. Here, it is shown that the crystallographic data can be fully explained by an alternative model, namely replacing the disaccharide with a buffer molecule. The conclusion is that the experimental data are likely to contain no information regarding the carbohydrate receptor binding site in GspB or the interaction of GspB with host cell receptors.
机译：最近已经提出了来自戈登链球菌的粘附素GspB的片段和二糖（PDB条目3qd1和4i8e）之间的复合物的结构，以鉴定由GspB识别的唾液酸-T抗原的结合位点。这种结构表现出许多不切实际和不寻常的特征，例如过多的范德华碰撞和原子结构与实验电子密度之间缺乏相关性。在此表明，晶体学数据可以用另一种模型充分解释，即用缓冲分子代替二糖。结论是实验数据可能不包含有关GspB中糖类受体结合位点或GspB与宿主细胞受体相互作用的信息。

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