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首页> 外文期刊>Acta Cytologica: The Journal of Clinical Cytology and Cytopathology >Cytomorphologic spectrum in paraganglioma.
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Cytomorphologic spectrum in paraganglioma.

机译：副神经节瘤的细胞形态学谱。

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摘要

OBJECTIVE: To study the detailed cytologic features of paragangliomas (PGs) and delineate features helpful in predicting behavior. STUDY DESIGN: We performed retrospective analysis of 12 cases cytologically suggested as PG over a period of 10 years. Smears were reviewed for cellularity, pattern, shape, cytoplasm, nuclear features and background. Cytologic diagnosis was correlated with clinicoradiologic features, histologic features and immunocytochemistry. RESULTS: Patient age ranged from 12 to 65 years, with male preponderance; they presented with a mass lesion. Sites involved were head and neck (5), retroperitoneum (5) and mediastinum (2). Smears were cellular; cells were round to oval, plasmacytoid and spindled and seen as scattered, in clusters, acinar and perivascular pattern. The most consistent feature was presence of pink granules. Pleomorphism was present in all but 1 case and less prominent in tumors with metastasis. Mitoses were more frequently seen in malignant cases. CONCLUSION: Cytologic features of PG are diverse. Although there are certain main features, they are not diagnostic unless combined with data on site, histology and ancillary studies. Presence of granules, mild pleomorphism, frequent mitoses and necrosis needs careful evaluation for malignancy potential and warrants close follow-up.
机译：目的：研究副神经节瘤（PGs）的详细细胞学特征并描述有助于预测行为的特征。研究设计：我们对10年来在细胞学上提示为PG的12例病例进行了回顾性分析。复查涂片的细胞性，模式，形状，细胞质，核特征和背景。细胞学诊断与临床放射学特征，组织学特征和免疫细胞化学有关。结果：患者年龄为12至65岁，男性占优势。他们表现出大块病变。涉及的部位是头部和颈部（5），腹膜后（5）和纵隔（2）。涂片为蜂窝状;细胞呈圆形至卵圆形，浆细胞样，纺锤形，散在簇状，腺泡和血管周围。最一致的特征是存在粉红色颗粒。除1例外，其余均存在多态性，在转移性肿瘤中不明显。线粒体在恶性病例中更常见。结论：PG的细胞学特征是多样的。尽管具有某些主要特征，但除非与现场数据，组织学和辅助研究相结合，否则它们无法诊断。存在颗粒，轻度多态性，频繁的有丝分裂和坏死需要仔细评估恶性潜能，并需要密切随访。

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