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首页> 外文期刊>Acta Cytologica: The Journal of Clinical Cytology and Cytopathology >Fine needle aspiration cytology of epithelioid angiosarcoma: a case report.
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Fine needle aspiration cytology of epithelioid angiosarcoma: a case report.

机译：上皮样血管肉瘤细针穿刺细胞学检查：一例报告。

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BACKGROUND: Malignant vascular tumors are rare. Few studies have described cytomorphologic features of hemangioendothelioma and angiosarcoma on fine needle aspiration cytology (FNAC). Malignant vascular tumor with epithelioid morphology can create diagnostic difficulty, as the cytology may simulate that in other nonvascular malignant tumors. We describe epithelioid angiosarcoma, diagnosed on FNAC, in which a differential diagnosis of histiocytosis and inflammatory granulation tissue was considered. CASE: A 20-year-old man presented with forehead and scalp swellings. The forehead lesion was radiologiocally associated with a lytic lesion in the bone. FNA resulted in high cellular yield, and smears revealed prominent vascular pattern with endothelial cell atypia and histiocytoid/epithelioid neoplastic cells, occasional mitotic figures and a few cells displaying nuclear grooving. Smear background showed a significant number of neutrophils. Epithelioid hemangioendothelioma/angiosarcoma, histiocytosis and inflammatory granulation tissue were considered. A cytologic diagnosis of epithelioid angiosarcoma/epithelioid hemangioendothelioma was suggested and confirmed on histopathologic and immunohistochemical examination. CONCLUSION: Cellular aspirates from malignant epithelioid endothelial tumors involving bone may be cytologically mistaken for histiocytosis and, rarely, inflammatory granulation tissue. However, prominent vascular pattern with striking endothelial cell atypia, presence of mitotic figures and careful search for presence of endothelial differentiation are helpful in accurate cytologic diagnosis.
机译：背景：恶性血管肿瘤很少见。很少有研究通过细针穿刺细胞学（FNAC）描述血管内皮瘤和血管肉瘤的细胞形态学特征。具有上皮样形态的恶性血管肿瘤会产生诊断困难，因为细胞学可能会模拟其他非血管恶性肿瘤中的情况。我们描述了在FNAC上诊断的上皮样血管肉瘤，其中考虑了组织细胞增生和炎性肉芽组织的鉴别诊断。病例：一名20岁男子出现额头和头皮肿胀。前额病变在放射性上与骨中的溶解性病变相关。 FNA导致高细胞产量，涂片显示出明显的血管形态，内皮细胞异型性和组织细胞样/上皮样赘生性细胞，偶见有丝分裂图和一些显示核切槽的细胞。涂片背景显示大量中性粒细胞。考虑上皮样血管内皮瘤/血管肉瘤，组织细胞增生和炎性肉芽组织。提出了上皮样血管肉瘤/上皮样血管内皮瘤的细胞学诊断，并在组织病理学和免疫组织化学检查中得到证实。结论：从恶性上皮样内皮细胞肿瘤累及骨的细胞抽吸物在细胞学上可能被误认为是组织细胞增生症，很少是炎症性肉芽组织。但是，明显的血管形态与明显的内皮细胞异型性，有丝分裂图的存在以及仔细寻找内皮分化的存在有助于准确的细胞学诊断。

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