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首页> 外文期刊>Acta Cytologica: The Journal of Clinical Cytology and Cytopathology >Morphologic, patient and interpreter profiles of high-risk human papillomavirus-positive vs.-negative cases of atypical squamous cells of undetermined significance.
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Morphologic, patient and interpreter profiles of high-risk human papillomavirus-positive vs.-negative cases of atypical squamous cells of undetermined significance.

机译：高危型人乳头瘤病毒阳性和阴性非典型鳞状细胞病例的形态学，患者和解释者资料未定。

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OBJECTIVE: To define the morphologic and patient profiles, if any, that distinguish high-risk human papillomavirus (HR-HPV)-positive atypical squamous cells of undetermined significance (ASCUS) from HR-HPV-negative ASCUS and to compare individual and laboratory reporting rates with the national averages. STUDY DESIGN: One hundred fifty liquid-based cervicovaginal preparations (ThinPrep, Cytyc Corporation, Boxborough, Massachusetts, U.S.A.) with a diagnosis of ASCUS and a reflex HR-HPV test were assessed for the following features: background patient information, cell morphology, cell patterns and interpreter profiles. Fisher's Exact test (2-tailed) was used to calculate the exact probability of obtaining results by chance. RESULTS: The median age of the HR-HPV-positive patients was approximately 11 years younger than the HPV-negative group, and pregnant patients were also more apt to be HPV positive. Atypical cells in greater numbers and in groups as opposed to single cells correlated more often with HR-HPV-positive individuals. Koilocytelike changes and parakeratosis were more frequently associated with HR-HPV, but the presence of Trichomonas was usually a negative predictor. CONCLUSION: In cases diagnosed as ASCUS, there are certain cytologic features and patient types that are more likely to be associated with HR-HPV positivity. This could be used in everyday practice to further fine tune the diagnosis of ASCUS. Monitoring individual and laboratory ASCUS rates with HR-HPV positivity can be an important quality improvement indicator.
机译：目的：定义形态学和患者特征（如果有），以区分高危人乳头瘤病毒（HR-HPV）阳性，具有未确定意义的非典型鳞状细胞（ASCUS）和HR-HPV阴性ASCUS，并比较个人和实验室报告率与全国平均水平。研究设计：评估了具有ASCUS诊断和反射性HR-HPV检测的150种基于液体的宫颈阴道制剂（ThinPrep，Cytyc Corporation，Boxborough，美国），其以下特征：患者背景信息，细胞形态，细胞模式和解释器配置文件。 Fisher精确检验（2尾）用于计算偶然获得结果的确切概率。结果：HR-HPV阳性患者的中位年龄比HPV阴性组年轻约11岁，并且孕妇也更倾向于HPV阳性。与单个细胞相反，非典型细胞的数量更多且成组，与HR-HPV阳性个体的关联更为频繁。 HR-HPV更常伴有类红细胞样变化和角化不全，但滴虫的存在通常是阴性预测因子。结论：在诊断为ASCUS的病例中，某些细胞学特征和患者类型更可能与HR-HPV阳性相关。这可以在日常实践中使用，以进一步优化ASCUS的诊断。用HR-HPV阳性监测个体和实验室ASCUS率可能是重要的质量改善指标。

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