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首页> 外文期刊>Acta Cytologica: The Journal of Clinical Cytology and Cytopathology >Galectin-3 cytotest in thyroid follicular neoplasia: a prospective, monoinstitutional study.
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Galectin-3 cytotest in thyroid follicular neoplasia: a prospective, monoinstitutional study.

机译：Galectin-3细胞试验在甲状腺滤泡性瘤形成中的前瞻性单研究。

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OBJECTIVE: To analyze the utility of galectin-3 (Gal3) immunohistochemistry (IHC) on preoperatively obtained fine needle aspiration biopsy (FNAB) in identifying the subgroup of follicular neoplasia (FN) patients who were candidates for thyroidectomy. STUDY DESIGN: This prospective, monoinstitutional study applied a standardized Gal3 immunostaining protocol (cell block specimens; Gal3 scores: G0 [no Gal3+ve IHC reaction], G1 [Gal3+ve thyrocytes < or = 10%], G2 [Gal3+ve thyrocytes > 10%) in 100 consecutive cytologically assessed FN. All patients underwent thyroidectomy, and the FNs were always histologically categorized (World Health Organization criteria). RESULTS: The overall malignancy rate was 15%. Gal3 expression in presurgical samples significantly correlated with the postoperative diagnosis (p < 0.0001). When all positive Gal3 cases were pooled together (G1+G2), the IHC test performed as follows: sensitivity = 80%; specificity = 86%; positive predictive value = 50%; negative predictive value = 96%. All the Gal3-G2 cases (presurgical cell block) showed postoperative evidence of malignancy. All 9 cases of papillary tumor expressed Gal3 in both cell block and postoperative histology. Among the 6 follicular cancers, the prevalence of Gal3 overexpression in the cell block was 50%. CONCLUSION: The cell block procedure applied to thyroid FNAB samples enables the Gal3 cytotest to be implemented usefully in the preoperative identification of those cases of FN postoperatively found to be malignant (also significantly reducing the number of inappropriate thyroidectomies). Strong Gal3 expression should prompt immediate surgical treatment.
机译：目的：分析galectin-3（Gal3）免疫组织化学（IHC）在术前获得的细针穿刺活检（FNAB）上的作用，以鉴定哪些甲状腺滤泡瘤（FN）患者可以进行甲状腺切除术。研究设计：这项前瞻性，单机构研究采用了标准化的Gal3免疫染色方案（细胞块标本; Gal3得分：G0 [无Gal3 + ve IHC反应]，G1 [Gal3 + ve甲状腺细胞<或= 10％]，G2 [Gal3 + ve 100个连续细胞学评估的FN中有10％以上的甲状腺细胞）。所有患者均进行了甲状腺切除术，并且FN始终按组织学分类（世界卫生组织标准）。结果：总的恶性率为15％。术前样本中的Gal3表达与术后诊断显着相关（p <0.0001）。当所有阳性Gal3病例合并在一起（G1 + G2）时，IHC测试如下：灵敏度= 80％;特异性= 86％;阳性预测值= 50％;阴性预测值= 96％。所有的Gal3-G2病例（术前细胞阻滞）均显示出恶性的术后证据。 9例乳头状瘤均在细胞阻滞和术后组织学中均表达Gal3。在这6种滤泡癌中，Gal3在细胞块中的过度表达率为50％。结论：对甲状腺FNAB样品进行的细胞阻断程序使Gal3细胞试验能够有效地用于术前鉴定术后发现为恶性的FN病例（也显着减少了不适当的甲状腺切除术的数量）。强烈的Gal3表达应立即进行手术治疗。

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