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首页> 外文期刊>Biomedical materials >Antibacterial activity and biocompatibility of zein scaffolds containing silver-doped bioactive glass
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Antibacterial activity and biocompatibility of zein scaffolds containing silver-doped bioactive glass

机译：含有银掺杂生物活性玻璃的抗菌活性和生物相容性

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摘要

Composite 3D scaffolds combining natural polymers and bioceramics are promising candidates for bone tissue engineering (BTE). Zein, as a natural plant protein, offers several advantages, including biocompatibility, adequate strength properties, and low/no immunogenicity; however, it lacks bioactivity. Thus, composite zein: bioactive glass (BG) scaffolds are proposed as promising candidate for BTE applications, with silver-doping of bioactive glass providing an antibacterial effect against possible post-implantation infection. Therefore, the aim of this study was to investigate the in vitro antibacterial properties, biocompatibility, bioactivity and compressive strength of zein scaffolds containing silver-doped bioactive glass. BGnanoparticles, undoped and Ag-doped, were fabricated using the sol-gel method. 3D composite zein:BG scaffolds, containing 20 wt% BG, were prepared and their antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was assessed using the disc diffusion assay. Human osteoblast-like MG-63 cells were used to evaluate the in vitro biocompatibility of the prepared scaffold groups. In addition, the compressive strength of the scaffolds was determined using uniaxial compression strength testing and the scaffold interconnected porosity was measured using helium pycnometer. Disc diffusion assay showed that only zein scaffolds containing Ag-doped sol-gel BGare antibacterially positive against E. coli and S. aureus. Pure zein scaffolds and zein scaffolds containing sol-gel-derived BG showed no negative influence on the growth of MG-63 cells, as evident by the cells' ability to survive, proliferate, and function on these scaffolds. Moreover, incorporating sol-gel-derived BGinto zein scaffolds at zein:BG of 80:20 ratio showed bioactive properties with adequate porosity without affecting the scaffolds' compressive strengths, which was similar to that of trabecular bone, suggesting that the new composites have potentia
机译：组合天然聚合物和生物陶瓷的复合3D支架是骨组织工程（BTE）的有希望的候选者。作为天然植物蛋白的玉米醇素提供了几种优点，包括生物相容性，足够的强度性能和低/无免疫原性;但是，它缺乏生物活性。因此，复合玉米醇溶蛋白：提出了生物活性玻璃（BG）支架作为BTE应用的有希望的候选者，具有对生物活性玻璃的银掺杂，提供抗菌效果，免于可能的植入后感染。因此，本研究的目的是研究含有银掺杂生物活性玻璃的玉米蛋白支架的体外抗菌性，生物相容性，生物活性和抗压强度。使用溶胶 - 凝胶法制造BGNANOPARTINGY，未掺杂和掺杂剂。 3D复合ZEIN：使用盘扩散测定评估含有20wt％Bg的BG支架，含有20wt％BG，含有对大肠杆菌（大肠杆菌）和金黄色葡萄球菌（S.UUREUS）的抗菌活性。人骨细胞样MG-63细胞用于评估制备的支架基团的体外生物相容性。另外，使用单轴压缩强度试验测定支架的压缩强度，并且使用氦pycnomet测量支架互连的孔隙率。盘扩散测定表明，只有含有Ag掺杂的溶胶 - 凝胶BGare的ZEIN支架抗菌阳性对大肠杆菌和金黄色葡萄球菌。含有溶胶 - 凝胶衍生的BG的纯玉米蛋白支架和玉米蛋白支架对Mg-63细胞的生长没有对Mg-63细胞的生长没有负面影响，因为细胞在这些支架上存活，增殖和功能的能力。此外，在玉米醇溶蛋白中掺入溶胶 - 凝胶衍生的Bginto Zein支架：BG为80:20的比例显示出具有足够孔隙率的生物活性性能而不影响支架的抗压强度，这与小梁骨骼相似，这表明新的复合材料具有高标复合材料

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  • 来源
    《Biomedical materials》 |2018年第6期|共13页
  • 作者

    Aiah A El-Rashidy; Gihan Waly; Ahmed Gad; Judith A Roether; Jasmin Hum; Yuyun Yang; Rainer Detsch; Azza A Hashem; Inas Sami; Wolfgang H Goldmann; Aldo R Boccaccini;

  • 作者单位

    Department of Biomaterials Faculty of Dentistry Cairo University 11562 Cairo Egypt;

    Department of Biomaterials Faculty of Dentistry Cairo University 11562 Cairo Egypt;

    Department of Animal Production Faculty of Agriculture Cairo University 12613 Giza Egypt;

    Institute of Polymer Materials University of Erlangen-Nuremberg D-91058 Erlangen Germany;

    Institute of Biomaterials University of Erlangen-Nuremberg D-91058 Erlangen Germany;

    Institute of Biomaterials University of Erlangen-Nuremberg D-91058 Erlangen Germany;

    Institute of Biomaterials University of Erlangen-Nuremberg D-91058 Erlangen Germany;

    Department of Biomaterials Faculty of Dentistry Cairo University 11562 Cairo Egypt;

    Department of Biomaterials Faculty of Dentistry Cairo University 11562 Cairo Egypt;

    Biophysics Group Department of Physics University of Erlangen-Nuremberg D-91052 Erlangen Germany;

    Institute of Biomaterials University of Erlangen-Nuremberg D-91058 Erlangen Germany;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用一般科学;
  • 关键词

    zein scaffolds; bioactive glass; silver; in vitro biocompatibility; antibacterial;

    机译：玉米蛋白脚手架;生物活性玻璃;银;体外生物相容性;抗菌;

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