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首页> 外文期刊>Biomedical materials >In vitro physical and biological characterization of biodegradable elastic polyurethane containing ferulic acid for small-caliber vascular grafts
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In vitro physical and biological characterization of biodegradable elastic polyurethane containing ferulic acid for small-caliber vascular grafts

机译：用于小口径血管移植物的生物降解弹性聚氨酯的体外物理和生物学特征

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摘要

Demand for small diameter vascular grafts is growing. The main limitations of these grafts include induced thrombotic events, lack of in situ endothelialization, intimal hyperplasia and poor mechanical properties which impair the graft patency rate in long-term applications. Most anti-thrombotic modification methods currently in use usually conflict with the formation of an endothelial cell monolayer on the grafts. Here, we synthesized a novel biodegradable poly(ether ester urethane)urea elastomer (PEEUU) using poly(ethylene glycol) and poly(diethylene glycol adipate) as soft segments. To improve hemocompatibility, synthesized PEEUU was blended with ferulic acid (FA). Scanning electron microscopy, water contact angle measurement, and tensile testing were used to characterize the scaffolds. The PEEUU and PEEUU-FA scaffolds revealed appropriate mechanical properties, with tensile strengths and strains similar to a coronary artery. In vitro assay demonstrated that the release of FA from the scaffold is in a sustained manner. Hemocompatibility tests indicated that the PEEUU-FA sample induced lower platelet adhesion compared to the PEEUU sample. Reductions in hemolysis and fibrinogen adsorption were detected on the PEEUU-FA sample. Cell studies showed that PEEUU-FA supported the adhesion, expansion and proliferation of endothelial cells. The cells maintained an endothelial cell phenotype through the expression of the endothelial cell marker CD31. The results revealed that the new PEEUU modified with FA can be considered as a promising candidate for vascular applications with enhanced blood compatibility and vascular cellcompatibility.
机译：对小直径血管移植的需求正在增长。这些移植物的主要局限性包括诱导的血栓性事件，缺乏原位内皮，内膜增生和机械性能差，这在长期应用中损害接枝通畅率。目前正在使用的大多数抗血栓形成修改方法通常与移植物上形成内皮细胞单层的形成。这里，我们使用聚（乙二醇）和聚（二乙二醇己二酸酯）作为软段，合成一种新型的可生物降解的聚（醚酯氨基甲酸酯）脲弹性体（PEEUU）。为了改善血液相作，合成的Peeuu与阿魏酸（Fa）混合。扫描电子显微镜，水接触角测量和拉伸试验用于表征支架。 Peeuu和Peeuu-FA支架揭示了适当的机械性能，其拉伸强度和类似于冠状动脉的菌株。体外测定证明，来自支架的Fa释放以持续的方式。血液相色试验表明，与Peeuu样品相比，Peeuu-FA样品诱导血小板粘附较低。在Peeuu-FA样品上检测到溶血和纤维蛋白原吸附的降低。细胞研究表明，Peeuu-Fa支持内皮细胞的粘附，膨胀和增殖。通过内皮细胞标记物CD31的表达，细胞保持内皮细胞表型。结果表明，用FA改性的新Peeuu可以被认为是具有增强血液相容性和血管纤维配置性的血管应用的有希望的候选者。

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  • 来源
    《Biomedical materials》 |2018年第3期|共11页
  • 作者

    Shiva Asadpour; Jafar Ai; Parivash Davoudi; Masoud Ghorbani; Marzie Jalali Monfared; Hossein Ghanbari;

  • 作者单位

    Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in Medicine (SATM) Tehran University of Medical Sciences (TUMS) Tehran Iran;

    Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in Medicine (SATM) Tehran University of Medical Sciences (TUMS) Tehran Iran;

    Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in Medicine (SATM) Tehran University of Medical Sciences (TUMS) Tehran Iran;

    Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in Medicine (SATM) Tehran University of Medical Sciences (TUMS) Tehran Iran;

    Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in Medicine (SATM) Tehran University of Medical Sciences (TUMS) Tehran Iran;

    Department of Medical Nanotechnology School of Advanced Technologies in Medicine (SATM) Tehran University of Medical Sciences (TUMS) Tehran Iran;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用一般科学;
  • 关键词

    vascular graft; polyurethane; ferulic acid; hemcompatibility; endothelial cells;

    机译：血管移植物;聚氨酯;阿魏酸;HEMCOMPASTIBLY;内皮细胞;

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