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首页> 外文期刊>BioEssays : >Developmental Transcriptional Enhancers: A Subtle Interplay between Accessibility and Activity Considering Quantitative Accessibility Changes between Different Regulatory States of an Enhancer Deconvolutes the Complex Relationship between Accessibility and Activity
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Developmental Transcriptional Enhancers: A Subtle Interplay between Accessibility and Activity Considering Quantitative Accessibility Changes between Different Regulatory States of an Enhancer Deconvolutes the Complex Relationship between Accessibility and Activity

机译：发育转录增强剂：考虑增强器的不同调节状态之间的定量可访问性之间的可访问性和活动之间的微妙相互作用在可访问性和活动之间的复杂关系中解作其识别

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Measurements of open chromatin in specific cell types are widely used to infer the spatiotemporal activity of transcriptional enhancers. How reliable are these predictions? In this review, it is argued that the relationship between the accessibility and activity of an enhancer is insufficiently described by simply considering open versus closed chromatin, or active versus inactive enhancers. Instead, recent studies focusing on the quantitative nature of accessibility signal reveal subtle differences between active enhancers and their different inactive counterparts: the closed silenced state and the accessible primed and repressed states. While the open structure as such is not a specific indicator of enhancer activity, active enhancers display a higher degree of accessibility than the primed and repressed states. Molecular mechanisms that may account for these quantitative differences are discussed. A model that relates molecular events at an enhancer to changes in its activity and accessibility in a developing tissue is also proposed.
机译：在特定细胞类型中的开放染色质的测量被广泛用于推断转录增强剂的时空活性。这些预测有多可靠？在该综述中，认为增强剂的可访问性和活动之间的关系通过简单地考虑开放与闭合染色质或活性与非活动增强剂来说不足。相反，近期研究专注于可访问性信号的定量性质揭示了有源增强器和其不同的非活动对应物之间的微妙差异：封闭的沉默状态和可访问的初步和压制状态。虽然开放结构不是增强器活动的特定指标，但是有源增强器显示比初步和压制状态更高的可访问性。讨论了可能占这些定量差异的分子机制。还提出了一种涉及增强剂在增强器中的分子事件以改变其活性和显影组织的可访问性的模型。

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