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Germline gene editing and the precautionary principle

机译:种系基因编辑和预防原则

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The precautionary principle aims to influence decision-making in contexts where some activity poses uncertain but potentially grave threats. This perfectly describes the controversy surrounding germline gene editing. This article considers whether the precautionary principle should influence how we weigh the risks and benefits of human germline interventions, focusing especially on the possible threats to the health of future generations. We distinguish between several existing forms of the precautionary principle, assess their plausibility and consider their implications for the ethics of germline modification. We also offer a novel form of the precautionary principle: the sufficientarian precautionary principle. Some plausible versions of the precautionary principle recommend placing somewhat greater weight on avoiding threats to future generations than on achieving short-term benefits. However, no plausible versions of the precautionary principle entail that we should outright reject the use germline gene editing in human reproduction and some, such as the sufficientarian version, might endorse its use.
机译:预防原则旨在影响一些活动的决策,其中一些活动造成不确定但潜在的严重威胁。这完美地描述了种系基因编辑的争议。本文考虑了预防原则应影响我们如何权衡人种种系干预的风险和益处,特别是对未来几代人健康的可能威胁。我们区分了几种现有的预防原则形式,评估其合理性,并考虑其对种种改性伦理的影响。我们还提供了一种新颖的预防原则:足够的预防原则。一些可粘合的原则版本建议在避免对后代的威胁方面施加更多的重量,而不是实现短期福利。然而,没有任何合理的预防原则的版本需要,我们应该彻底拒绝在人类繁殖中进行使用的种系基因,以及一些,例如足够的版本,可能支持其使用。

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