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首页> 外文期刊>Biofabrication >Introducing biomimetic shear and ion gradients to microfluidicspinning improves silk fiber strength
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Introducing biomimetic shear and ion gradients to microfluidicspinning improves silk fiber strength

机译：将仿生剪切和离子梯度引入MicroFluidicspinning，提高了丝纤维强度

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Silkworm silk is an attractive biopolymer for biomedical applications due to its high mechanicalstrength and biocompatibility; as a result, there is increasing interest in scalable devices to spin silk andrecombinant silk so as to improve and customize their properties for diverse biomedical purposes(Vepari and Kaplan 2007 Prog. Polym. Sci. 32). While artificial spinning of regenerated silk fibroinsadds tunability to properties such as degradation rate and surface functionalization, the resultingfibers do not yet approach the mechanical strength of native silkworm silk. These drawbacks reducethe applicability and attractiveness of artificial silk (Kinahan et al 2011 Biomacromolecules 12). Here,we used computational fluid dynamic simulations to incorporate shear in tandem with biomimeticion gradients by coupling a modular novel glass microfluidic device to our previous co-axial flowdevice. Fibers spun with this combined apparatus demonstrated a significant increase in mechanicalstrength compared to fibers spun with the basic apparatus alone, with a three-fold increase in Young’smodulus and extensibility and a twelve-fold increase in toughness. These results thus demonstrate thecritical importance of ionic milieu and shear stress in spinning strong fibers from solubilized silkfibroin.
机译：蚕丝是一种有吸引力的生物医学应用，其由于其高机械高电平和生物相容性;结果，对旋转丝和颗粒丝绸的可伸缩装置的兴趣越来越兴趣，以改善和定制它们的性质以获得各种生物医学目的（vepari和Kaplan 2007 Prog。Polym.32）。虽然再生丝纤维素的人工纺丝可调性，但诸如降解率和表面官能化等性的性质，但是结果却尚不接近天然蚕丝的机械强度。这些缺点减少了人造丝的适用性和吸引力（Kinahan等人2011 BioMacromologules 12）。这里，我们使用计算流体动态模拟通过将模块化新颖的玻璃微流体装置耦合到我们先前的共轴线流动的生物细胞梯度，用生物细胞梯度掺入剪切。使用该组合装置旋转的纤维显示出与单独用基本设备的纤维纺丝相比，机械精力的显着增加，幼小胚胎增加三倍，韧性增加12倍。因此，这些结果表明了离子Milieu和剪切应力在旋转来自溶解的丝丝蛋白的强纤维中的欺骗性重要性。

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