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High-altitude adaptation of yak based on genetic variants and activity of lactate dehydrogenase-1.

机译：基于遗传变体和乳酸脱氢酶-1的活性的牦牛高空适应。

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This study investigates the molecular mechanism by which yaks (Bos grunniens) adapt to hypoxia based on lactate dehydrogenase (LDH). Three LDH1 variants of the yak were revealed in tissue extracts by electrophoresis, including LDH1-F, LDH1-M, and LDH1-S. Kinetic analysis using purified LDH1 variants showed that the yak LDH1-M variant exhibited a similar K (m) (NADH) and the same mobility on a gel as bovine LDH1, and the LDH1-F variant showed significant differences in K (m) values for NADH or pyruvate from the other two variants of yak LDH1 and bovine LDH1. Among the three muscles assayed, yak longissimus dorsi showed the highest LDH activity and the lowest malate dehydrogenase (MDH) activity; heart muscle was exactly the opposite. Our results suggest that the three LDH1 variants might play an important role in the adaptation to hypoxia.
机译：本研究研究了基于乳酸脱氢酶（LDH）的牦牛（BOS Grunniens）适应缺氧的分子机制。 通过电泳，包括LDH1-F，LDH1-M和LDH1-S的组织提取物中揭示了牦牛的三个LDH1变体。 使用纯化的LDH1变体的动力学分析显示YAK LDH1-M变体在凝胶中表现出类似的K（M）（NADH）和与牛LDH1的相同迁移率，并且LDH1-F变体显示出K（M）值的显着差异 对于来自牦牛LDH1和牛LDH1的其他两个变体的NADH或丙酮酸。 在测定的三个肌肉中，Yak Longissimus Dorsi显示出最高的LDH活性和最低的苹果酸脱氢酶（MDH）活性; 心肌正是相反的。 我们的研究结果表明，三个LDH1变体可能在适应缺氧中发挥重要作用。

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