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首页> 外文期刊>Biochemical Genetics >Genetic Variation at 15 Autosomal STR Loci Among Seven Egyptian Populations
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Genetic Variation at 15 Autosomal STR Loci Among Seven Egyptian Populations

机译：七个埃及人群中15个常染色体STR基因座的遗传变异

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摘要

Egypt is a transcontinental country containing substantial ethnic, cultural, and linguistic diversity among its people. This study was conducted to investigate the genetic variation at 15 AmpFlSTR Identifiler short tandem repeat (STR) loci, D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, and FGA, within and between seven Egyptian populations. Samples of 814 unrelated individuals from Northern Coast, Delta, Greater Cairo, Canal governorates, Northern Upper Egypt, Southern Upper Egypt, and Sinai were investigated. All loci were highly polymorphic in all sample populations. The data were analyzed to give information on allele frequencies and other population statistical parameters. After applying Bonferroni correction, the agreement with Hardy-Weinberg equilibrium (HWE) was confirmed for all loci (exact test), and for all loci with the exception of D3S1358, D19S433, and D18S51 (X-2 test). The levels of genetic differentiation and the genetic relationships among populations were evaluated by coefficient of genetic differentiation (F-ST), AMOVA, and genetic distance of Nei. The most differentiated populations were found between Sinai and Southern Upper Egypt. These two populations showed the lowest within-population variation, whereas the population of Greater Cairo showed the highest within-population variation as indicated by the fixation index F-IS. The varying levels of genetic relatedness among the populations in relation to their geographical distribution were analyzed using Mantel test. The results demonstrated that the effectiveness of STR markers enhances their value for identifying the genetic variation within and between Egyptian populations.
机译：埃及是一个跨越的国家，含有大量的民族，文化和语言多样性。该研究进行了研究以研究15AMPFLSTR识别器短串联重复（STR）基因座，D8S1179，D21S11，D7S820，​​CSF1PO，D3S1358，D13S317，D16S539，D2S138，D19S43，VWA，TPOX，D18S51，D5S818和FGA，七个埃及人口之间。研究了来自北部海岸，三角洲，大开罗，运河省，北埃及，南部埃及南部埃及和西奈州的814个无关的人。所有基因座在所有样本群体中都是高度多态性的。分析数据以提供有关等位基因频率和其他人口统计参数的信息。在申请Bonferroni修正之后，对所有基因座（精确测试）确认了与Hardy-Weinberg均衡（HWE）的协议，以及除D3S1358，D19S433和D18S51（X-2检验）外，所有基因座通过遗传分化（F-ST），Amova和Nei的遗传距离来评估遗传分化水平和群体的遗传关系。西奈和南部埃及之间发现了最差异化的人群。这两种种群显示出群体内部的最低变异，而大开店的人口显示出最高的群体变异，如固定指数F-IS所示。使用Mantel试验分析了与其地理分布相关的群体中遗传相关程度的变化相关性。结果表明，STR标记的有效性增强了它们的价值来识别埃及人群内部和之间的遗传变异。

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