• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochemical Genetics >Association of the rs1870634 Variant in Long Intergenic Non-protein Coding RNA 841 with Coronary Artery Disease: A GWAS-Replication Study in an Iranian Population
【24h】

Association of the rs1870634 Variant in Long Intergenic Non-protein Coding RNA 841 with Coronary Artery Disease: A GWAS-Replication Study in an Iranian Population

机译：具有冠状动脉疾病的长期非蛋白质编码RNA 841中的RS1870634变体的关联：伊朗人口的GWAS复制研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent genome-wide association studies (GWAS) identified a list of single-nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD). Replication of GWAS findings in different population corroborated the observed association in the parent GWAS. In this study, we aimed to replicate the association of rs1870634 , a GWAS identified SNP, to CAD in an Iranian population. The study population consisted of 267 subjects undergoing coronary angiography coronary angiography including 155 CAD patients and 112 non-CAD age- and gender-matched controls. The genotype determination of rs1870634 SNP performed using high-resolution melting analysis (HRM) technique. Our results revealed that the GG genotype frequency was significantly higher in CAD patients compared with controls ( P? =?0.03). The results of binary logistic regression suggested that this genotype was significantly associated with CAD risk adjustment for age, BMI, sex, TC, and LDL-C lipid levels (OR of 2.78, 95% CI (1.10–7.01), P? =?0.03). Moreover, our results showed that the GG+TG genotypes were 2.52 times more likely to develop CAD (95% CI 1.05–6.03) than TT genotype carriers after adjusting for age, sex, and lipid profiles ( P? =?0.037). These data showed that the GG genotype could be associated with increased risk of CAD in a sample of Iranian population.
机译：最近的基因组关联研究（GWAs）鉴定了与冠状动脉疾病（CAD）相关的单核苷酸多态性（SNP）列表。不同人口GWAS发现的复制证实了父gwas中观察到的关联。在这项研究中，我们旨在复制RS1870634的协会，GWAS确定的SNP，在伊朗人口中的CAD。该研究人群由267名受试者组成，经历冠状动脉造影冠状动脉造影，包括155名CAD患者和112名非CAD和性别匹配的对照。使用高分辨率熔化分析（HRM）技术进行RS1870634 SNP的基因型测定。我们的研究结果表明，CAD患者的GG基因型频率明显高于对照组（P？= 0.03）。二元逻辑回归的结果表明，该基因型与年龄，BMI，性别，TC和LDL-C脂质水平（或2.78,95％CI（1.10-7.01），P？=？ 0.03）。此外，我们的结果表明，在调整年龄，性别和脂质曲线（P = 0.037）后，GG + TG基因型比TT基因型载体更容易产生CAD（95％CI 1.05-6.03）的可能性比TT基因型载体更少2.52倍。这些数据表明，GG基因型可能与伊朗人群样本中CAD的风险增加有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号