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首页> 外文期刊>Biochemical Genetics >High MHC DQB variation and asymmetric allelic distribution in the endangered Yangtze finless porpoise, Neophocaena phocaenoides asiaeorientalis.
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High MHC DQB variation and asymmetric allelic distribution in the endangered Yangtze finless porpoise, Neophocaena phocaenoides asiaeorientalis.

机译：高MHC DQB变异和不对称等位基因分布在濒临灭绝的长江氟化水，Neophocaena Phocaenoides Asiaeorientalis。

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摘要

The endangered Yangtze finless porpoise is found in the middle and lower reaches of the Yangtze River and its adjoining big lakes. To explore the major histocompatibility complex (MHC) genetic diversity and allelic distribution patterns across its range, we investigated variation at DQB exon 2. From 76 porpoises, we identified 18 DQB sequences. The freshwater Yangtze populations had much higher allelic diversity than marine populations. Among these freshwater populations, the middle-reach population had higher allelic diversity than the lower-reach population. The high DQB diversity level, relative to that of a neutral mtDNA locus, suggests that balancing selection is acting at the DQB gene and that rapid evolution and local positive selection play critical roles in generating and retaining high MHC diversity in the freshwater population. As the balancing selection might be driven by environmental pathogens, we suggest that maintaining MHC variation should be a high priority in the conservation and management of this endangered population, especially as an ex situ conservation strategy.
机译：濒临灭绝的长江无翅膀的海豚在长江的中下游和毗邻的大湖泊。为了探讨其范围内的主要组织相容性复合物（MHC）遗传多样性和等位基因分布模式，我们研究了DQB外显子2的变化。从76个Porpoises，我们确定了18个DQB序列。淡水长江种群比海洋群体更高的异教徒多样性。在这些淡水群中，中息人口的等位基因多样性较高，而不是较低达人口。相对于中性MTDNA基因座的高DQB分集水平表明，平衡选择在DQB基因作用，并且快速进化和局部阳性选择在淡水群中产生和保持高MHC多样性起到关键作用。由于平衡选择可能是由环境病原体驱动的，我们建议维持MHC变异应该是这种濒危人群的保护和管理的高度优先事项，特别是作为以非原位保护策略为例。

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