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首页> 外文期刊>Biochemical Genetics >High MHC DQB variation and asymmetric allelic distribution in the endangered Yangtze finless porpoise, Neophocaena phocaenoides asiaeorientalis.
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High MHC DQB variation and asymmetric allelic distribution in the endangered Yangtze finless porpoise, Neophocaena phocaenoides asiaeorientalis.

机译：在濒临灭绝的长江无鳍海豚，Neophocaena phocaenoides asiaeorientalis中，高MHC DQB变异和不对称等位基因分布。

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摘要

The endangered Yangtze finless porpoise is found in the middle and lower reaches of the Yangtze River and its adjoining big lakes. To explore the major histocompatibility complex (MHC) genetic diversity and allelic distribution patterns across its range, we investigated variation at DQB exon 2. From 76 porpoises, we identified 18 DQB sequences. The freshwater Yangtze populations had much higher allelic diversity than marine populations. Among these freshwater populations, the middle-reach population had higher allelic diversity than the lower-reach population. The high DQB diversity level, relative to that of a neutral mtDNA locus, suggests that balancing selection is acting at the DQB gene and that rapid evolution and local positive selection play critical roles in generating and retaining high MHC diversity in the freshwater population. As the balancing selection might be driven by environmental pathogens, we suggest that maintaining MHC variation should be a high priority in the conservation and management of this endangered population, especially as an ex situ conservation strategy.
机译：濒临灭绝的长江无鳍海豚在长江中下游及其毗邻的大湖中发现。为了探究主要组织相容性复合体（MHC）的遗传多样性和等位基因在其范围内的分布模式，我们研究了DQB外显子2的变异。从76只海豚中，我们鉴定出18个DQB序列。长江淡水种群比海洋种群具有更高的等位基因多样性。在这些淡水种群中，中游种群比低种群种群具有更高的等位基因多样性。相对于中性mtDNA基因座而言，较高的DQB多样性水平表明，平衡选择作用于DQB基因，快速进化和局部阳性选择在淡水种群中产生并保持较高的MHC多样性方面起着关键作用。由于平衡选择可能是由环境病原体驱动的，因此我们建议保持MHC的变异性在这一濒临灭绝的种群的保护和管理中应是当务之急，尤其是作为非原生境保护策略。

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