...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochemical Genetics >A Strong Relationship Between Oral Squamous Cell Carcinoma and DNA Repair Genes
【24h】

A Strong Relationship Between Oral Squamous Cell Carcinoma and DNA Repair Genes

机译：口腔鳞状细胞癌和DNA修复基因之间的强大关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Single nucleotide polymorphisms of DNA repair genes alter protein function and modulate DNA repair efficiency in various cancers. The X-ray repair cross-complementing group (XRCC) is responsible for the repair of DNA base damage and single-strand breaks. The aim of our study was to investigate the association of XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms with the susceptibility to develop oral squamous cell carcinoma (OSCC) in Turkish subjects. One hundred eleven patients with OSCC and 148 healthy controls were recruited for the study. Genetic analysis was performed using polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP). We found that the XRCC1 Arg399Gln Gln/Gln genotype and Gln allele were risk factors for OSCC. Also, Arg/Arg genotype and Arg allele had protective effects against OSCC. Relative to XRCC3 Thr241Met polymorphism, carrying homozygote variants (Thr/Thr and Met/Met) was related with elevated OSCC risk. However, the heterozygote genotype and Thr allele variants were shown to be protective against OSCC. We suggest that XRCC1 Arg399Gln Gln/Gln genotype, Gln allele, and homozygote variants of XRCC3 Thr241Met polymorphism may be a risk factor for predisposition of OSCC in Turkish. In addition, XRCC3 Thr241Met genotype could be associated with tumor size and level of daily smoking.
机译：摘要单核苷酸多态性DNA修复基因改变蛋白质功能并调节各种癌症的DNA修复效率。 X射线修复交叉互补组（XRCC）负责修复DNA碱损伤和单链断裂。我们的研究目的是探讨XRCC1 Arg399GLN和XRCC3 THR241MET多态性与土耳其对象中口腔鳞状细胞癌（OSCC）的易感性的敏感性。研究了一百11例OSCC和148名健康对照的研究。使用聚合酶链反应/限制性片段长度多态性（PCR / RFLP）进行遗传分析。我们发现XRCC1 Arg399GLN Gln / Gln基因型和Gln等位基因是OSCC的危险因素。此外，Arg / Arg基因型和Arg等位基因对OSCC具有保护作用。相对于XRCC3 THR241MET多态性，携带HOMOZYGOTE变体（THR / THR和MET / MET）与OSCC风险升高。然而，杂合出基因型和Thr等位基因变体被证明对OSCC保护。我们建议XRCC1 ARG399GLNGLN / GLN基因型，GLN等位基因和XRCC3 THR241MET多态性的纯合理变异可能是在土耳其语中易受OSCC的易感性的危险因素。此外，XRCC3 Thr241met基因型可能与肿瘤大小和日常吸烟水平相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号