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首页> 外文期刊>Biochemical Genetics >Genetic Polymorphisms of CCDC26 rs891835, rs6470745, and rs55705857 in Glioma Risk: A Systematic Review and Meta-analysis
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Genetic Polymorphisms of CCDC26 rs891835, rs6470745, and rs55705857 in Glioma Risk: A Systematic Review and Meta-analysis

机译：CCDC26 RS891835，RS6470745和胶质瘤风险rs55705857的遗传多态性：系统评价和荟萃分析

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摘要

A genetic component is accepted in the etiology of the glioma. Evidence from candidate genes studies and GWAS reveal that CCDC26 gene could increase the risk of glioma. We performed a systematic review and up-to-date meta-analysis to explore if polymorphisms of CCDC26 gene (rs891835, rs6470745, and rs55705857) may be a susceptibility factor in developing glioma. An online search in PubMed, Web of Science, and SCOPUS up to September 2018 was performed. The pooled odds ratios were evaluated by fixed effects model and random effects model. Analyses of the overall sample and ethnic sub-groups were performed. In all the analyses, the allelic, additive, dominant, and recessive models were used. We found an association between all polymorphisms evaluated and an increased risk for glioma in the overall population in all the models studied. In sub-group analysis, we found that rs891835 and rs6470745 increased the risk of glioma in Europeans and Caucasians. On the other hand, the rs891835 polymorphism did not reveal any statistical association in Chinese population. Taken into consideration the limitations of this study, the present findings suggest a possible participation of rs891835, rs6470745, and rs55705857 as risk factors to develop glioma. Furthermore, it is possible that the involvement of CCDC26 variants depends on ethnicity. However, we recommend to perform further studies to have conclusive outcomes.
机译：在胶质瘤的病因中接受遗传组分。来自候选基因研究和GWAS的证据表明CCDC26基因可以增加胶质瘤的风险。我们进行了系统审查和最新的荟萃分析，探讨CCDC26基因的多态性（RS891835，RS6470745和RS55705857）可能是显影胶质瘤的易感因素。在2018年9月的PubMed，科学网站和Scopus中进行在线搜索。通过固定效果模型和随机效果模型评估汇集的差距。进行整个样本和族群分组的分析。在所有分析中，使用等位基因，添加剂，显性和隐性模型。我们发现所有多态性之间的关联和研究的所有模型中的整体人群中胶质瘤的风险增加。在子组分析中，我们发现RS891835和RS6470745增加了欧洲和高加索人的胶质瘤风险。另一方面，RS891835多态性没有揭示中国人口中的任何统计会。考虑到本研究的局限性，目前的研究结果表明，RS891835，RS6470745和RS55705857的可能参与是开发胶质瘤的风险因素。此外，CCDC26变体的参与可能取决于种族。但是，我们建议进行进一步的研究以具有决定性的结果。

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