...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochemical Pharmacology >Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis
【24h】

Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis

机译：小檗碱通过抑制SCAP / SREBP-1信号通路介导的脂肪生成来抑制结肠癌细胞增殖

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lipid metabolism is a significant section of energy homeostasis, and it affects the development of various cancers. Previous studies have revealed that berberine has strong anticancer and blood lipid-lowering effects. Here, we further investigated the effects of berberine on cell proliferation and lipogenesis in colon cancer cells and the relationship between the two effects. We found that berberine inhibited cell proliferation by inducing G0/G1 phase cell cycle arrest in colon cancer cells. Moreover, the expressions of key lipogenic enzymes were down-regulated by berberine and led to the suppressed lipid synthesis, which was linked to cell proliferation via Wnt/beta-catenin pathway. Importantly, berberine inhibited sterol regulatory element-binding protein-1 (SREBP-1) activation and SREBP cleavage-activating protein (SCAP) expression, resulting in the downregulation of these lipogenic enzymes. Knockdown of SCAP by shRNA could abolish the effect of berberine on SREBP-1 activation. Besides the inhibitory effects in vitro, berberine suppressed the growth and lipogenesis of colon cancer xenograft in a SCAP-dependent manner as well. Together, our results suggest that berberine may serve as a candidate against tumor growth of colon cancer partially through targeting SCAP/SREBP-1 pathway driving lipogenesis.
机译：脂质代谢是能量稳态的重要部分，它会影响各种癌症的发展。以前的研究表明，小檗碱具有强烈的抗癌和血脂降低效果。在这里，我们进一步研究了小檗碱对结肠癌细胞中细胞增殖和脂肪生成的影响以及两种效应之间的关系。我们发现，伯伯琳通过在结肠癌细胞中诱导G0 / G1相细胞周期停滞来抑制细胞增殖。此外，通过小檗碱对关键脂质酶的表达下调，并导致抑制脂质合成，通过Wnt /β-连环蛋白途径与细胞增殖连接。重要的是，小檗碱抑制甾醇调节元素结合蛋白-1（SreBP-1）活化和Srebp切割激活蛋白（SCAP）表达，导致这些脂质酶的下调。 ShRNA敲除可以废除Berberine对Srebp-1激活的影响。除了体外抑制作用外，小檗碱也抑制了结肠癌异种移植的生长和脂肪生成，以及依赖于突出的方式。我们的结果表明，小檗碱可以作为抗结肠癌肿瘤生长的候选者，其部分通过靶向SCAP / SREB-1途径驱动脂肪生成。

著录项

  • 来源
    《Biochemical Pharmacology》 |2020年第1期|共13页
  • 作者

    Liu Yunxin; Hua Weiwei; Li Yao; Xian Xirui; Zhao Zheng; Liu Chao; Zou Jianjun; Li Jun; Fang Xianjun; Zhu Yubing;

  • 作者单位

    Nanjing Med Univ Nanjing Hosp 1 Dept Pharm 68 Changle Rd Nanjing 210029 Peoples R China;

    China Pharmaceut Univ Sch Basic Med &

    Clin Pharm Nanjing 211198 Peoples R China;

    China Pharmaceut Univ Sch Basic Med &

    Clin Pharm Nanjing 211198 Peoples R China;

    China Pharmaceut Univ Sch Basic Med &

    Clin Pharm Nanjing 211198 Peoples R China;

    Nanjing Med Univ Nanjing Hosp 1 Dept Pharm 68 Changle Rd Nanjing 210029 Peoples R China;

    Nanjing Med Univ Nanjing Hosp 1 Dept Pharm 68 Changle Rd Nanjing 210029 Peoples R China;

    Nanjing Med Univ Nanjing Hosp 1 Dept Pharm 68 Changle Rd Nanjing 210029 Peoples R China;

    Nanjing Med Univ Nanjing Hosp 1 Dept Pharm 68 Changle Rd Nanjing 210029 Peoples R China;

    Anhui Med Univ Affiliated Hosp 1 Dept Pharm 218 Jixi Rd Hefei 230022 Peoples R China;

    Nanjing Med Univ Nanjing Hosp 1 Dept Pharm 68 Changle Rd Nanjing 210029 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Berberine; Lipogenesis; SCAP; SREBP-1; Colon cancer;

    机译：小檗碱;脂肪生成;SCAP;srebp-1;结肠癌;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号