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首页> 外文期刊>Biochemical Pharmacology >Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in na?ve and Aβ-treated female rats
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Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in na?ve and Aβ-treated female rats

机译：N-3 PUFA富集和N-3 PUFA缺乏饮食在Naα患者和Aβ治疗的女大鼠中的影响

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Depression is one of the most common psychiatric diseases and the prevalence of depressive symptoms in women is almost twice compared to men, although the reasons of this gender difference are not fully understood yet. Recently, soluble Aβ1–42peptide has been receiving great importance in the development of depression, also since depression is highly comorbid with Alzheimer’s disease and other neurodegenerative illnesses. Accordingly, we have previously shown that central Aβ injection is able to elicit depressive-like phenotype in male rats. In the present study, we reproduced for the first time the Aβ-induced depressive-like model in female rats, evaluating behavioural and neurochemical outcomes. Moreover, we studied the effect of lifelong exposure to either n-3 PUFA enriched or n-3 PUFA deficient diet, in female rats, both intact and after central Aβ administration. Our results confirmed the Aβ-induced depressive-like profile also in female rats. Moreover, chronic exposure to n-3 PUFA deficient diet led to highly negative alterations in behavioural and neurochemical parameters, while lifelong exposure to n-3 PUFA enriched diet was able to restore the Aβ-induced depressive-like profile in female rats. In conclusion, the Aβ-induced depressive-like profile was reversed by n-3 PUFA supplementation, indicating a possible therapeutic role of n-3 PUFA in the treatment of the burden of depressive disorders.
机译：抑郁症是最常见的精神病疾病之一，与男性相比，女性抑郁症状的患病率几乎是两次，但尚未完全理解这种性别差异的原因。最近，可溶性Aβ1-42肽在抑郁症的发展中得到了重视，因为抑郁症与阿尔茨海默病和其他神经退行性疾病高度合并。因此，我们之前已经表明，中央Aβ注射能够在雄性大鼠中引发抑郁样表型。在本研究中，我们首次复制了雌性大鼠的Aβ诱导的抑郁型模型，评估行为和神经化学结果。此外，我们研究了终身暴露于N-3 Pufa富集或N-3 Pufa缺乏饮食中的雌性大鼠的效果，无需在中央Aβ给药后。我们的结果证实了雌性大鼠的Aβ诱导的抑郁状曲线。此外，慢性暴露于N-3 PUFA缺乏饮食导致行为和神经化素参数的高度负变化，而终身暴露于N-3富氮饮食能够恢复雌性大鼠的Aβ诱导的抑郁型曲线。总之，Aβ诱导的抑郁型曲线通过N-3 PUFA补充反转，表明N-3 PUFA在治疗抑郁症负担中的可能治疗作用。

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