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首页> 外文期刊>Biochemical Pharmacology >Fluid shear stress sensing in vascular homeostasis and remodeling: Towards the development of innovative pharmacological approaches to treat vascular dysfunction
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Fluid shear stress sensing in vascular homeostasis and remodeling: Towards the development of innovative pharmacological approaches to treat vascular dysfunction

机译：血管稳态和重塑中的流体剪切应激感应：朝向血管功能障碍的创新药理学方法的发展

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摘要

Blood circulation, facilitating gas exchange and nutrient transportation, is a quintessential feature of life in vertebrates. Any disruption to blood flow, may it be by blockade or traumatic rupture, irrevocably leads to tissue infarction or death. Therefore, it is not surprising that hemostasis and vascular adaptation measures have been evolutionarily selected to mitigate the adverse consequences of altered circulation. Blood vessels can be broadly categorized as arteries, veins, or capillaries, based on their structure, hemodynamics, and gas exchange. However, all of them share one property: they are lined with an epithelial sheet called the endothelium, which typically lies on a basement membrane. This endothelium is the primary interface between the flowing blood and the rest of the body, and it has highly specialized molecular mechanisms to detect and respond to changes in blood perfusion. The purpose of this commentary will be to highlight some of the recent developments in the research on blood flow sensing, vascular remodeling, and homeostasis and to discuss the development of innovative pharmaceutical approaches targeting mechanosensing mechanisms to prolong patient survival and improve quality of life.
机译：血液循环，促进煤气交换和营养运输，是脊椎动物的典型生活特征。对血流的任何破坏，可能是通过阻断或创伤破裂，不可撤销地导致组织梗死或死亡。因此，止血和血管适应措施已经进化地选择了止血和血管适应措施并不令人惊讶以减轻改变循环的不良后果。基于其结构，血流动力学和煤气交换，血管可广泛分为动脉，静脉或毛细血管。然而，所有这些都分享一个物业：它们衬有一种称为内皮的上皮片，通常位于基底膜上。这种内皮是流动血液和身体其余部分之间的主要界面，并且具有高度专业的分子机制来检测和响应血液灌注的变化。该评论的目的是突出血液流动传感，血管重塑和稳态研究的一些发展，并讨论创新药物方法的发展，瞄准机械静电机制以延长患者生存，提高生活质量。

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