Microglia-derived extracellular vesicles in Alzheimer's Disease: A double-edged sword

Trotta Teresa; Panaro Maria Antonietta; Cianciulli Antonia; Mori Giorgio; Di Benedetto Adriana; Porro Chiara

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Microglia-derived extracellular vesicles in Alzheimer's Disease: A double-edged sword

机译：在阿尔茨海默病中微胶质细胞外囊囊泡：一把双刃剑

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Extracellular vesicles (EVs), based on their origin or size, can be classified as apoptotic bodies, microvesides (MVs)/microparticles (MPS), and exosomes. EVs are one of the new emerging modes of communication between cells that are providing new insights into the pathophysiology of several diseases. EVs released from activated or apoptotic cells contain specific proteins (signaling molecules, receptors, integrins, cytokines), bioactive lipids, nucleic acids (mRNA, miRNA, small non coding RNAs, DNA) from their progenitor cells.

机译：基于其来源或尺寸的细胞外囊泡（EVS）可以被分类为凋亡体，微缺酰基（MVS）/微粒（MPS）和外泌体。 EVS是在为几种疾病的病理生理学提供新的洞察的细胞之间的新出现模式之一。从活性或凋亡细胞释放的EVS含有特定的蛋白质（信号传导分子，受体，整联，细胞因子），来自祖细胞的核细胞的生物活性脂质，核酸（mRNA，小非编码RNA，DNA）。

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来源
《Biochemical Pharmacology》 |2018年第2018期|共9页
作者
Trotta Teresa; Panaro Maria Antonietta; Cianciulli Antonia; Mori Giorgio; Di Benedetto Adriana; Porro Chiara;
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作者单位

Univ Foggia Dept Clin &

Expt Med Foggia Italy;

Univ Bari Dept Biosci Biotechnol &

Biopharmaceut Bari Italy;

Univ Bari Dept Biosci Biotechnol &

Biopharmaceut Bari Italy;

Univ Foggia Dept Clin &

Expt Med Foggia Italy;

Univ Foggia Dept Clin &

Expt Med Foggia Italy;

Univ Foggia Dept Clin &

Expt Med Foggia Italy;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
EVs; Microglia; Alzheimer's Disease; Neuroinflammation; Neurodegeneration; Biomarkers;

机译：EVS;MICROGLIA;阿尔茨海默病;神经炎症;神经变性;生物标志物;

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专利

1. Microglia-derived extracellular vesicles in Alzheimer's Disease: A double-edged sword [J] . Trotta Teresa, Panaro Maria Antonietta, Cianciulli Antonia, Biochemical Pharmacology . 2018,第期

机译：在阿尔茨海默病中微胶质细胞外囊囊泡：一把双刃剑
2. Rapamycin and Alzheimer disease: a double-edged sword? [J] . Carosi Julian M., Sargeant Timothy J. Autophagy . 2019,第8期

机译：雷帕霉素和阿尔茨海默病：双刃剑？
3. Reactive astrocytes in Alzheimer’s disease: A double-edged sword [J] . Heejung Chun, C. Justin Lee Neuroscience Research: The Official Journal of the Japan Neuroscience Society . 2018,第期

机译：阿尔茨海默病的活性星形胶质细胞：一把双刃剑
4. Detection of micro ribonucleic acids from extracted extracellular vesicles for cardiovascular diseases by using an integrated microfluidic system [C] . Hong-Lin Cheng, Chien-Yu Fu, Yen-Wen Chen, IEEE Micro Electro Mechanical Systems Conference . 2018

机译：使用集成的微流控系统检测提取的用于心血管疾病的细胞外囊泡中的微核糖核酸
5. Spin Labeled Fluorene Compounds are a Versatile Sword in the Fight Against Amyloid Beta Peptide of Alzheimer's Disease. [D] . Hilt, Silvia. 2016

机译：自旋标记的芴化合物是对抗阿尔茨海默氏病淀粉样β肽的多用途剑。
6. Correction to: Extracellular Vesicles in Neurodegenerative Diseases: A Double-Edged Sword [O] . Ji Yong Lee, Han-Soo Kim 2018

机译：校正至：神经退行性疾病中的细胞外囊泡：双刃剑
7. Microglia-Derived Extracellular Vesicles Carrying miR-711 Alleviate Neurodegeneration in a Murine Alzheimer’s Disease Model by Binding to Itpkb [O] . Yizhi Zhang, Chengbi Xu, Yi Nan, 2020

机译：携带miR-711的微胶质细胞外细胞内囊泡通过与ITPKB结合来缓解小鼠阿尔茨海默病的疾病模型中的神经变性

Microglia-derived extracellular vesicles in Alzheimer's Disease: A double-edged sword

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