首页> 外文期刊>Acta biomaterialia >Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment
【24h】

Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment

机译:工程学上的意外发现:高通量发现抗细菌附着的材料

获取原文
获取原文并翻译 | 示例
           

摘要

Controlling the colonisation of materials by microorganisms is important in a wide range of industries and clinical settings. To date, the underlying mechanisms that govern the interactions of bacteria with material surfaces remain poorly understood, limiting the ab initio design and engineering of biomaterials to control bacterial attachment. Combinatorial approaches involving high-throughput screening have emerged as key tools for identifying materials to control bacterial attachment. The hundreds of different materials assessed using these methods can be carried out with the aid of computational modelling. This approach can develop an understanding of the rules used to predict bacterial attachment to surfaces of non-toxic synthetic materials. Here we outline our view on the state of this field and the challenges and opportunities in this area for the coming years.
机译:在许多行业和临床环境中,控制微生物对材料的定殖很重要。迄今为止,控制细菌与材料表面相互作用的潜在机制仍然知之甚少,从而限制了从头开始设计和工程改造生物材料以控制细菌的附着。涉及高通量筛选的组合方法已成为识别材料以控制细菌附着的关键工具。使用这些方法评估的数百种不同材料可以借助计算模型进行。这种方法可以增进对用于预测细菌附着到无毒合成材料表面的规则的理解。在这里,我们概述了我们对该领域的现状以及未来几年该领域的挑战和机遇的看法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号