Search for Intracellular Sensors Involved in the Functioning of Monovalent Cations as Secondary Messengers

Klimanova E. A.; Sidorenko S. V.; Tverskoi A. M.; Shiyan A. A.; Smolyaninova L. V.; Kapilevich L. V.; Gusakova S. V.; Maksimov G. V.; Lopina O. D.; Orlov S. N.

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Search for Intracellular Sensors Involved in the Functioning of Monovalent Cations as Secondary Messengers

机译：搜索涉及单价阳离子作为次要信使的功能的细胞内传感器

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Maintenance of non-equilibrium Na+ and K+ distribution between cytoplasm and extracellular medium suggests existence of sensors responding with conformational transitions to the changes of these monovalent cations' intracellular concentration. Molecular nature of monovalent cation sensors has been established in Na,K-ATPase, G-protein-coupled receptors, and heat shock proteins structural studies. Recently, it was found that changes in Na+ and K+ intracellular concentration are the key factors in the transcription and translation control, respectively. In this review, we summarize results of these studies and discuss physiological and pathophysiological significance of Na-i(+),K-i(+)-dependent gene expression regulation mechanism.

机译：细胞质和细胞外培养基之间的非平衡Na +和K +分布的维持表明，在这些单价阳离子细胞内浓度的变化中响应的传感器的存在。在Na，K-ATP酶，G蛋白偶联的受体中建立了单价阳离子传感器的分子性质和热休克蛋白结构研究。最近，发现Na +和K +细胞内浓度的变化分别是转录和翻译控制中的关键因素。在本文中，我们总结了这些研究的结果，并讨论了Na-I（+），K-I（+）依赖性基因表达调控机制的生理和病理生理学意义。

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《Biochemistry》 |2019年第11期|共16页
作者
Klimanova E. A.; Sidorenko S. V.; Tverskoi A. M.; Shiyan A. A.; Smolyaninova L. V.; Kapilevich L. V.; Gusakova S. V.; Maksimov G. V.; Lopina O. D.; Orlov S. N.;
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作者单位

Lomonosov Moscow State Univ Dept Biol Moscow 119234 Russia;

Lomonosov Moscow State Univ Dept Biol Moscow 119234 Russia;

Lomonosov Moscow State Univ Dept Biol Moscow 119234 Russia;

Lomonosov Moscow State Univ Dept Biol Moscow 119234 Russia;

Lomonosov Moscow State Univ Dept Biol Moscow 119234 Russia;

Natl Res Tomsk State Univ Tomsk 634050 Russia;

Siberian State Med Univ Minist Hlth Russian Federat Tomsk 634050 Russia;

Lomonosov Moscow State Univ Dept Biol Moscow 119234 Russia;

Lomonosov Moscow State Univ Dept Biol Moscow 119234 Russia;

Lomonosov Moscow State Univ Dept Biol Moscow 119234 Russia;

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正文语种 eng
中图分类生物化学;
关键词
sodium; potassium; transcription; translation;

机译：钠;钾;转录;翻译;

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专利

1. Search for Intracellular Sensors Involved in the Functioning of Monovalent Cations as Secondary Messengers [J] . Klimanova E. A., Sidorenko S. V., Tverskoi A. M., Biochemistry . 2019,第11期

机译：搜索涉及单价阳离子作为次要信使的功能的细胞内传感器
2. Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger HO, and protein chaperones. [J] . Rhee SG, Woo HA Antioxidants and redox signalling . 2011,第3期

机译：过氧化物酶的多种功能：过氧化物酶，细胞内信使HO的传感器和调节剂以及蛋白伴侣。
3. Functional proteins involved in regulation of intracellular Ca(2+) for drug development: the extracellular calcium receptor and an innovative medical approach to control secondary hyperparathyroidism by calcimimetics. [J] . Nagano N, Nemeth EF Journal of pharmacological sciences. . 2005,第3期

机译：功能蛋白参与细胞内Ca（2+）的药物开发调控：细胞外钙受体和一种创新的医学方法来通过拟钙剂控制继发性甲状旁腺功能亢进。
4. Interaction of prestin (SLC26A5) with monovalent intracellular anions [C] . Dominik Oliver, Thorsten Schachinger, Bernd Fakle Symposium on Epithelial anion transport in health and disease: the role of the SLC26 transporters family . 2006

机译：普雷斯汀（SLC26A5）与一价细胞内阴离子的相互作用
5. Design, synthesis, and evaluation of fluorescent sensors for intracellular imaging of monovalent copper. [D] . Yang, Liuchun. 2006

机译：用于单价铜细胞内成像的荧光传感器的设计，合成和评估。
6. Monovalent cation (MC) current in cardiac and smooth muscle cells: regulation by intracellular Mg2+ and inhibition by polycations [O] . Sergey I Zakharov, Tarik Smani, Endri Leno, 2003

机译：心脏和平滑肌细胞中的单价阳离子（MC）电流：通过细胞内Mg2 +的调节和多阳离子的抑制
7. Molecular pharmacology of intracellular Ca2+ messenger system in cardiovascular function: Development and application of selective inhibitors. [O] . Hiroyoshi HIDAKA 1992

机译：心血管功能细胞内Ca2 +信使系统的分子药理：选择性抑制剂的开发与应用。
8. Radio Frequency Controlled Stimulation of Intracellular Gold or Silver Nanoparticle Conjugates for Use as Potential Sensors or Modulators of Biological Function [R] . Murdock, R. C., Hussain, S. M. 2010

机译：射频控制刺激细胞内金或银纳米粒子共轭物用作潜在传感器或生物功能调节剂

Search for Intracellular Sensors Involved in the Functioning of Monovalent Cations as Secondary Messengers

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