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Spatial Structure of Glycogen Molecules in Cells

机译:细胞中糖原分子的空间结构

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摘要

Glycogen is a strongly branched polymer of alpha-D-glucose, with glucose residues in the linear chains linked by 1 - 4-bonds (similar to 93% of the total number of bonds) and with branching after every 4-8 residues formed by 1 - 6-glycosidic bonds (similar to 7% of the total number of bonds). It is thought currently that a fully formed glycogen molecule (beta-particle) with the self-glycosylating protein glycogenin in the center has a spherical shape with diameter of similar to 42 nm and contains similar to 55,000 glucose residues. The glycogen molecule also includes numerous proteins involved in its synthesis and degradation, as well as proteins performing a carcass function. However, the type and force of bonds connecting these proteins to the polysaccharide moiety of glycogen are significantly different. This review presents the available data on the spatial structure of the glycogen molecule and its changes under various physiological and pathological conditions.
机译:糖原是α-D-葡萄糖的强支化聚合物,用1 - &gt连接的线性链中的葡萄糖残基。 4-键(相似键总数的93%)和在1 - &gt形成的每4-8个残基后的支化。 6-糖苷键(类似于键总数的7%)。 目前认为,中心的完全形成的糖原分子(β-颗粒)在中心中具有自糖基化蛋白糖原蛋白的球形,其直径与42nm相似,含有类似于55,000葡萄糖残基。 糖原分子还包括许多蛋白质,涉及其合成和降解,以及执行胎体功能的蛋白质。 然而,将这些蛋白质与糖原的多糖部分连接到多糖部分的键的类型和力显着不同。 本综述介绍了糖原分子的空间结构及其在各种生理和病理条件下的变化的可用数据。

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