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The Repertoire of Human Antiglycan Antibodies and Its Dynamics in the First Year of Life

机译：人类抗原抗体的曲目及其在生命的第一年的动态

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摘要

The repertoire of antiglycan antibodies of peripheral blood was studied using a microarray containing 487 glycan antigens: fragments of mammalian glycans (N- and O-chains of glycoproteins, as well as glycolipids) and also bacterial poly-saccharides. The sera samples correspond to the third, sixth, and twelfth months of life. The infants were divided into four groups according to their nutrition type: breast milk, standard formula, and partially or extensively hydrolyzed formula. During the first year of life, the total amount of IgG decreased; presumably, the lifetime of maternal IgG in the newborns' bloodstream is much greater than is generally assumed. At the same time, the IgM content was low during the first six months and increased significantly by the twelfth month. The antiglycan IgM repertoire of one-year-old infants was still different from that of their mothers, as well as from the repertoire of unrelated donors, in particular, by the absence of antibodies against the Gal1-3GlcNAc (Le(C)) disaccharide, which is found in almost all healthy humans. It is noteworthy that the level of IgM of breast-fed infants was significantly lower than that of formula-fed by the twelfth month.
机译：使用含有487甘油抗原的微阵列研究外周血的抗原抗体的反谱：哺乳动物聚糖的片段（糖蛋白的N-和O-链，以及糖脂）以及细菌聚糖。血清样本对应于生命的第三个，第六和第十二个月。根据其营养型分为四组：母乳，标准配方和部分或广泛的水解式。在生命的第一年，IgG的总量减少;据推测，新生儿血液中的母体IgG的寿命远大于通常假设。与此同时，在前六个月内，IgM含量低，第十二个月显着增加。一岁的婴儿的抗原IGM曲目仍然与母亲的反恐，以及从不相关的捐助者的曲目，特别是由于缺乏针对Gal1-3GlCNAc（Le（C））二糖的抗体，在几乎所有健康的人类中都存在。值得注意的是，母乳喂养婴儿的IgM水平明显低于第十二个月的公式喂养。

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