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首页> 外文期刊>Cytokine >Cytokine release from placental endothelial cells, a process associated with preterm labour in the absence of intrauterine infection.
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Cytokine release from placental endothelial cells, a process associated with preterm labour in the absence of intrauterine infection.

机译：细胞因子从胎盘内皮细胞释放，这与在没有宫内感染的情况下早产有关。

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There is currently a great deal of interest in the role that cytokines may play in the processes mediating preterm as well as normal term labour. In case of preterm delivery a cause-effect relationship between infection, uncontrollable preterm labour, and increased uterine cytokine concentrations is widely accepted, but there is considerable information that increased uterine cytokine release is also a condition in normal term labour and preterm labour not due to infection. Thereby, the exact cellular sources of cytokine production have not yet been identified. In the present study, the authors used immunohistochemical analysis to localize interleukin 1beta (IL-1beta) interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-alpha) immunoreactivity within trophoblastic villi and fetal membranes. In the absence of chorioamnionitis, uncontrollable preterm labour, and also normal term labour was associated with strong immunoreactivity for IL-1beta and IL-6 in the endothelial cells within trophoblastic villi. In contrast, preterm delivery accompanied by histologically confirmed chorioamnionitis, was not associated with increased expression of cytokine antigens within endothelial cells of the fetal vascular system, but strong cytokine activity was found in polymorphonuclear cells infiltrating the amniochorionic membranes. Therefore, the data suggest two well-defined subgroups among patients delivering preterm. Thereby, increased uterine cytokine concentrations may be realized in both groups, but the cellular sources of cytokine production may be different. Copyright 1999 Academic Press.
机译：目前，细胞因子在介导早产和正常足月劳动的过程中可能扮演的角色引起了人们的极大兴趣。在早产的情况下，感染，无法控制的早产和子宫细胞因子浓度升高之间的因果关系已被广泛接受，但是有相当多的信息表明，子宫细胞因子释放的增加也是正常足月和早产中的一种情况，并非由于感染。因此，尚未确定细胞因子产生的确切细胞来源。在本研究中，作者使用免疫组织化学分析在滋养细胞绒毛和胎儿膜内定位白介素1β（IL-1beta）白介素6（IL-6）和肿瘤坏死因子α（TNF-alpha）免疫反应性。在没有绒毛膜羊膜炎的情况下，无法控制的早产以及正常足月分娩与滋养细胞绒毛内内皮细胞中IL-1β和IL-6的强免疫反应性有关。相反，早产并伴有组织学证实的绒毛膜羊膜炎，与胎儿血管系统内皮细胞内细胞因子抗原的表达增加无关，但在渗透到羊膜绒毛膜的多形核细胞中发现强的细胞因子活性。因此，数据提示早产患者中有两个明确定义的亚组。因此，两组中均可实现增加的子宫细胞因子浓度，但是细胞因子产生的细胞来源可能不同。版权所有1999，学术出版社。

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