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首页> 外文期刊>Biological & pharmaceutical bulletin >Kappa Opioid Receptor Agonist Administration in Olfactory Bulbectomized Mice Restores Cognitive Impairment through Cholinergic Neuron Activation
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Kappa Opioid Receptor Agonist Administration in Olfactory Bulbectomized Mice Restores Cognitive Impairment through Cholinergic Neuron Activation

机译：Kappa阿片受体激动剂在嗅囊肿中的诱导小鼠通过胆碱能神经元激活恢复认知障碍

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摘要

Olfactory bulbectomized (OBX) mice are characterized by impaired performance in the passive avoidance test and decreased number of cholinergic neurons in the hippocampus. Several studies have reported that K-opioid receptor agonists improve cognitive function in mice. However, their influence on OBX-induced cognitive dysfunction remains unclear. To address this question, we evaluated the effects of the endogenous K-opioid receptor agonist dynorphin A (Dyn A) and the selective agonist trans-(-)-U-50488 on the behavior of OBX mice in the passive avoidance test. The cognitive dysfunction of OBX mice was significantly recovered by the intracerebroventricular administration of Dyn A or trans-(-)-U-50488. The effects of these two agonists were counteracted by the selective K-opioid receptor antagonist nor-binaltorphimine or the inhibitor of acetylcholine release beta-bungarotoxin. These findings suggest that K-opioid receptor agonists produce anti dementia effects through activation of cholinergic neurons in OBX mice.
机译：嗅到血管囊肿（OBX）小鼠的特征在于在被动避免试验中的性能受损，并且海马中的胆碱能神经元数减少。若干研究报道了K-阿片受体激动剂改善小鼠的认知功能。然而，它们对OBX诱导的认知功能障碍的影响仍然不清楚。为了解决这个问题，我们评估了内源性K-阿片受体激动剂Dynorphin A（DyN A）和选择性激动剂反式（ - ） - U-50488对被动避免试验中OBX小鼠的行为的影响。逆型A或反式（ - ） - U-50488的脑内施用施用致抗OBX小鼠的认知功能障碍。通过选择性K-阿片受体拮抗剂NOR-BINARINE拮抗剂或乙酰胆碱释放β-BUNGALOTOXIN的抑制剂抵消了这两个激动剂的效果。这些发现表明K-阿片类受体激动剂通过在OBX小鼠中激活胆碱能神经元产生抗痴呆效应。

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  • 作者

    Takahashi Kohei; Nakagawasai Osamu; Sugawara Masae; Sato Atsushi; Nemoto Wataru; Tadano Takeshi; Tan-No Koichi;

  • 作者单位

    Tohoku Med &

    Pharmaceut Univ Fac Pharmaceut Sci Dept Pharmacol Aoba Ku 4-4-1 Komatsushima Sendai Miyagi 9818558 Japan;

    Tohoku Med &

    Pharmaceut Univ Fac Pharmaceut Sci Dept Pharmacol Aoba Ku 4-4-1 Komatsushima Sendai Miyagi 9818558 Japan;

    Tohoku Med &

    Pharmaceut Univ Fac Pharmaceut Sci Dept Pharmacol Aoba Ku 4-4-1 Komatsushima Sendai Miyagi 9818558 Japan;

    Tohoku Med &

    Pharmaceut Univ Fac Pharmaceut Sci Dept Pharmacol Aoba Ku 4-4-1 Komatsushima Sendai Miyagi 9818558 Japan;

    Tohoku Med &

    Pharmaceut Univ Fac Pharmaceut Sci Dept Pharmacol Aoba Ku 4-4-1 Komatsushima Sendai Miyagi 9818558 Japan;

    Kanazawa Univ Grad Sch Med Sci Complementary &

    Alternat Med Clin Res &

    Dev Kanazawa Ishikawa 9208640 Japan;

    Tohoku Med &

    Pharmaceut Univ Fac Pharmaceut Sci Dept Pharmacol Aoba Ku 4-4-1 Komatsushima Sendai Miyagi 9818558 Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    olfactory bulbectomy; memory; kappa-opioid; cholinergic neuron;

    机译：嗅到泛骨;记忆;kappa-opioid;胆碱能神经元;

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