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首页> 外文期刊>Biological chemistry >IL-6 type cytokine receptor complexes: hexamer, tetramer or both?
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IL-6 type cytokine receptor complexes: hexamer, tetramer or both?

机译：IL-6型细胞因子受体复合物：六聚体，四聚体或两者？

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摘要

The typical protein fold of most cytokines is a bundle of four antiparallel helices. This 'four-helical bundle fold' seems to be unique to cytokines and has not been detected in other proteins. Cytokine receptors, however, can be classified as a subfamily of the immunoglobulin superfamily. Cytokines using the same receptor subunits are grouped into cytokine families. The interleukin-6 (IL-6) type cytokine family comprises six members. IL-6 type cytokines may interact with three receptor subunits instead of the usual two subunits. A tetramer would be the simplest model to describe such a receptor complex, but present orthodoxy describes the active complexes of IL-6 and ciliary neurotrophic factor (CNTF) as hexamers. Here, we summarize the structural and biochemical information on IL-6 type cytokines and discuss interactions between cytokine and individual receptor subunits at alternative positions. Contradictory results regarding the stoichiometry and assembly of signaling receptor complexes are rationalized by a new, unique model. The model stipulates that a ligand-induced transition from an active tetrameric to an inactive hexameric complex serves as a molecular switch that turns off cytokine signals in the presence of supraoptimal cytokine concentrations.
机译：大多数细胞因子的典型蛋白质折叠是一束四个反双星螺旋。这种“四螺旋束折叠”似乎是细胞因子的独特性，并且尚未在其他蛋白质中检测到。然而，细胞因子受体可以被分类为免疫球蛋白超家族的亚家族。使用相同的受体亚基的细胞因子被分组成细胞因子家族。白细胞介素-6（IL-6）型细胞因子家族包含六个成员。 IL-6型细胞因子可以与三个受体亚基相互作用而不是通常的两个亚基。四聚体是描述这种受体复合物的最简单模型，但是存在正统描述IL-6和纤毛神经营养因子（CNTF）的活性复合物作为六烷烃。在这里，我们总结了IL-6型细胞因子上的结构和生化信息，并讨论替代位置的细胞因子和个体受体亚基之间的相互作用。关于传导受体复合物的化学计量和组装的矛盾结果是通过新的独特模型合理化的。该模型规定，从活性四聚体与无活性六聚体复合物的配体诱导的过渡用作分子开关，其在中羟化细胞因子浓度存在下关闭细胞因子信号。

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